交联聚磷酸酯的合成及其释药性能研究  

Synthesis of Crosslinked Polyphosphates and Drug Release

作　　者：罗毅[1] 卓仁禧[1] 范昌烈[1] 

机构地区：[1]北京大学化学系,武汉大学化学系

出　　处：《高等学校化学学报》1995年第10期1633-1636,共4页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金

摘　　要：以（ｉ－Ｂｕ）_３Ａｌ为引发剂研究了２－氢－氧－１，３，２－二氧五环磷酸酯，２－氢－２－氧－１，３，２－二氧六环磷酸酯的开环均聚和共聚合反应，然后经过氯化、水解获得了交联聚磷酸酯材料。以合成的交联聚磷酸酯为药物载体，采用单层骨架片、双层骨架片和夹心片的载药方式，对抗肿瘤药物５－氟尿嘧啶进行了控制释放，获得了较好的释药效果。Ring-opening polymerizations of 2-hydro-2-oxo-3,2-dioxa-phospholan and/or2-hydro-2-oxo-1,3,2-dioxaphosphorinane were studied using(i-Bu3)Al as initiator. After chlorination and hydrolysis, crosslinked polymers were obtained.The in vitro release of 5-fluorouracil from its single-matrix pellets,double-layered pellets and sandwich pellet with the crosslinked polyphosphates as drug carriers were carried out in phosphate buffer solution(pH 7.4)at 37℃. Sustained release from the sandwich pellet was more controlled than that from the single-matrix pellets and double-layered pellets.

关 键 词：磷酸酯 氟尿嘧啶 释药性能 

分 类 号：O627.51[理学—有机化学] R318.08[理学—化学]