O－糖基－甲氧甲酰基膦酰胺酯的合成及其生物活性研究  

Studies on the Syntheses and Biological Activities of O-Saccharidyl-methoxyformylphosphonamidates

作　　者：陈小茹[1] 陈茹玉[1] 李慧 毛丽娟[1] 

机构地区：[1]南开大学元素有机化学研究所

出　　处：《高等学校化学学报》1995年第12期1899-1902,共4页Chemical Journal of Chinese Universities

基　　金：国家自然科学青年基金;天津市21世纪青年基金

摘　　要：合成了一系列新型Ｏ－糖基－甲氧甲酰基膦酰胺酯，并对Ｏ－糖基亚磷酰胺酯与氯甲酸甲酯的Ａｒｂｕｚｏｖ反应及其它有关反应进行了讨论。产物的结构经~１ＨＮＭＲ、^（３１）ＰＮＭＲ、ＩＲ及元素分析确定。初步的生物活性测定结果表明，化合物３_ｅ对人肝癌Ｂｅｌ－７４０２细胞和人白血病ＨＬ－６０细胞有一定的抑制作用。化合物３ａ对烟草花叶病毒有一定的抑制活性．A series of novel O-saccharidyl-methoxyformylphosphosphonamidates were synthesized,and Arbuzov reaetions of O-saccharidylphosphoramidites with methyl chloroformate and other related reactions were disussed.The structures of the products were determined by￣1H NMR,￣(31)P NMR, IR and elemental analyses. The results of preliminary biological tests showed that compound 3_c possessed some inhibitory activities against Leukaemia HL-60 cells and liver cancer Bel-7402 cells in vitro,compound 3_a has some antivirus activity against tobacco mosaic virus(TMV).

关 键 词：甲酰基膦酰胺酯 抗癌 抗病毒 有机磷 

分 类 号：O627.51[理学—有机化学] R979.1[理学—化学]