高甘油三酯血症患者载脂蛋白B基因的MspI多态性研究  

The MspI Polymorphisms of the Apolipoprotein B Gene in Hypertriglyceridaemic Patients

作　　者：赵若智[1] 赵宗彦[1] 刘锡民[2] 蔡转[2] 

机构地区：[1]北京医科大学人民医院神经内科,100044 [2]同济医科大学同济医院,武汉430030

出　　处：《高血压杂志》1995年第4期279-281,共3页Chinese Journal of Hypertension

摘　　要：利用Apo B cDNA探针（LB 1.5）,检测13名高甘油三酯血症（HTG）患者和21名正常对照者的Apo B基因MspI限制性片段长度多态性（RFLP）等位基因频率。研究结果显示,34份标本共出现2.35kb（M_1）和2.60kb（M_2）二种不同长度的杂交片段。M_2等位基因频率在HTG患者（0.192）和对照者（0.024）之间存在明显差异（P=0.02）。With an Apo B cDNA probe(LB 1. 5), we investigated MspI allele frequencies of restriction fragment length polymorphisms (RFLP) of the apolipoprotein B(Apo B) gene in 13 hypertriglyc-eridaemic (HTG) patients and 21 healthy subjects, The result showed that 2. 35 kb(M1) and 2. 60 kb (M2) hybridization fragments were found in 34 sam-ples. The rare allele(M2) was seen more frequently in patients than in controls (0. 192 vs 0. 024,P = 0. 02).

关 键 词：高甘油三酯血症 载脂蛋白 多态性 

分 类 号：R589.202[医药卫生—内分泌]