高原慢性缺氧对大鼠脑纹状体内β—内啡肽含量影响  

THE ENFLUENCE OF HIGH ALTITUDE CHRONIC HYPOXIA ON THE CONTENTS OF B EP IN CORPUS STRIATUM

作　　者：孟宪纪[1] 谢新民[1] 白若华[1] 都玉蓉 

机构地区：[1]青海医学院,青海师大生物系

出　　处：《高原医学杂志》1995年第2期42-43,共2页Journal of High Altitude Medicine

摘　　要：木工作选用标化Ｗｉｓｔａｒ大鼠，由平原（上海，海拔５ｍ）直接引入高原（青海天峻，海拔３４６０ｍ）低氧环境，用放射免疫法（落ＲＩＡ）研究了大鼠在３０天慢性习服期间，脑纹状体内β—内啡肽样免疫活性物质（β—ＥＰ）含量的变化。结果表明，１～３天纹状体内β—ＥＰ的含量超于增加，３天后开始下降，至３０天下降非常显著，统计学处理有非常显著性差异（Ｐ＜０．０１）。提示，β—ＥＰ与高原低氧有密切的关系，可能参与高原习服的调节过程。istar ratsbrought fromsea leve(5m)were studied at Tian Jun,3 460m for B EP with ra-dioimmunoassay for 30 days.The results wrere as follows,the contents of β EP increased in thefirst three days,then began to decrease,and at the 30th day it decreased significantly(P<0.01)。The restults suggested that the β EP may take part in the adaption of rats to the hypoxia.

关 键 词：高原环境 缺氧 Β内啡肽 纹状体 

分 类 号：R339.54[医药卫生—人体生理学]