氟对人体血清免疫功能的影响  

EFFECTS OF FLUORIDE ON IMMUNE FUNCTION IN HUMAN

作　　者：宋世震[1] 刘建东[1] 陈荣安[1] 张国高[1] 

机构地区：[1]同济医科大学劳动卫生教研室

出　　处：《工业卫生与职业病》1995年第5期280-281,共2页Industrial Health and Occupational Diseases

摘　　要：本文用酶联免疫吸附试验、单向免疫扩散等方法检测了氟暴露工人血清可溶性白细胞介素２受体（ＳＩＬ－２Ｒ），α肿瘤坏死因子（ＴＮＦα）和免疫球蛋白ＩｇＡ、ＩｇＭ、ＩｇＧ。结果显示工人血清ＴＮＦα含量与氟暴露工龄有关，表现为短期氟暴露工人ＴＮＦα增加，而长期氟暴露工人ＴＮＦα降低。ＳＩＬ－２Ｒ及ＩｇＡ、ＩｇＭ、ＩｇＧ含量则两者之间无明显差异。提示氟对暴露工人免疫功能的影响呈双向性。The contents of serum soluble interleukin 2 receptor (SIL-2R),tumor necrosis factor α(TNFα)and IgA, IgM,IgG were measured by ELISA or radio-immunodiffusion technique in fluoride ex posed workers. The results showed that level of serum TNFα was significantly increased in group A and apparently decreased in group B. There were no differences in contents of SIL-2R and IgA,IgM, IgG among three groups. It is suggested that the influence of fluoride on immune function could possess two-way action.

关 键 词：氟暴露 白细胞介素2 受体 肿瘤坏死因子 

分 类 号：R994.3[医药卫生—毒理学]