氟暴露对工人外周血AKP、SOD、GSH－PX活性的影响及“抗氟灵”的拮抗作用研究  

STUDY ON EFFECT OF FLUORIDE EXPOSURE AND ANTI-FLUORIDE EFFECT OF‘KANGFULING’ON ACTIVITIES OF AKP,SOD,GSH-PX IN PERIPHERAL BLOOD OF WORKERS

作　　者：刘建东[1] 刘脏 陈荣安[1] 章孟本[1] 苏希华 南涤飞 党志敏[1] 段美兰[1] 

机构地区：[1]同济医科大学劳动卫生与职业病教研室

出　　处：《工业卫生与职业病》1995年第5期272-274,共3页Industrial Health and Occupational Diseases

基　　金：中国有色金属总公司"八五"项目

摘　　要：选择氟暴露工龄５年以上的男性工人４０名，随机分为Ａ、Ｂ两组，每组２０人，Ａ组为服药组，Ｂ组为非服药组；另选非氟暴露工人１５名为阴性对照组（Ｃ组），观察“抗氟灵”抗氟损伤效果。结果表明，氟暴露工人外周血ＡＫＰ、ＧＳＨ－ＰＸ活性、尿Ｆ－、ＢＦ４－含量明显高于非氟暴露组工人，而血清ＳＯＤ活性则相反。服药后，Ａ组以上各指标除ＧＳＨ－ＰＸ变化不显著外，其它指标均有显著性改变，其中血清ＡＫＰ活性和尿Ｆ－含量降低，且明显低于Ｂ组；血清ＳＯＤ活性和尿ＢＦ４－含量显著升高，且明显高于Ｂ组。揭示“抗氟灵”对氟损伤的拮抗有一定效果。To evaluate the preventive anti-damage effect of Kangfuling' on fluoride ,40 males exposed to fluoride more than 5 years were randomly and equally divided into 2 groups,A&B.Group A was used as medicine taking group,and group B as a positive control group. At the same time,15 males unexposed to fluoride were used as a negative control group, group C.The results revealed that before taking the medicine, the activities of AKP,GSHPX in peripheral blood and the concentrations of F,BF-4 in urine in group A and B were higher than those in group C, with the exception of SOD. After taking the medicine,in group A the activity of AKP and the concentration of F- in urine decreased except GSH-PX,while the activity of SOD and the concentration of BF4- in urine increased significantly. However,all varieties in group B and C varied not significantly. The results proved the preventive anti-damage effect of 'Kangfuling'on fluoride.

关 键 词：氟暴露 抗氟灵 拮抗作用 

分 类 号：R135[医药卫生—劳动卫生]