赛庚啶对5-羟色胺抑制体感皮层诱发单位放电作用的影响  

Effect of Cyproheptadine on 5-HT in Inhibiting Evoked Unit Discharges of Primary Somatosensory Cortex

作　　者：陈钟伦[1] 刘甘泉[1] 姚愈忠[1] 陈培熹[1] 

机构地区：[1]中山医科大学生理教研室

出　　处：《广东药学院学报》1995年第2期79-81,共3页Academic Journal of Guangdong College of Pharmacy

基　　金：美国中华医学基金

摘　　要：用Ｗｉｓｔａｒ大鼠在氨基甲酸乙酯麻醉下研究微电泳５－羟色胺（５－ＨＴ）和５－ＨＴ２受体拮抗剂赛庚啶对大脑皮层第一体感区诱发单位放电（ＳＩ－ＥＵＤ）有无明显影响。结果表明５－ＨＴ在５－２０ｎＡ时对ＳＩ－ＥＵＤ无明显影响；４０－１６０ｎＡ时，有抑制或易化作用，以抑制作用为主；赛庚啶可拮抗５－ＨＴ对ＳＩ－ＥＵＤ的抑制作用。提示５－ＨＴ２受体可能参与５－ＨＴ对ＳＩ－ＥＵＤ单位的抑制作用。The effects of microiontophoretically applled 5-hydroxyptamine(5-HT)andcyprohetadine on evoked unit discharges of primary somatosensory cortex(SI-EUD) in Wistar ratsanesthetized with urethane were investigated. The results showed that:(1) When 5-20nA of 5- HT was applied,no obvious effect of 5-HT on SI-EUD was found.When 40-16onA of 5-HTwas applied,both inhibitory and faeilitating effects of 5-HT on SI-EUD were observed , the majoteffect being inhibitory.(2)The inhibitory effect of 5-HT on SI-EUD could be bloked by Cypro-heptamine(antagonist of 5-HT2 receptors).It is suggested that 5-HT2 receptors may be inxolvedin medicating the 5-HT inhibitory effect on SI-EUD.

关 键 词：赛庚啶 大脑皮层 第一体感区 血清素 

分 类 号：R338.25[医药卫生—人体生理学]