狂犬疫苗联用抗狂犬病血清的免疫效果探讨  

STUDY ON IMMUNITY EFFECT OFTHE COMBINED RABIES VACCINEAND ANTIRABIES SERUM

作　　者：叶秀英[1] 

机构地区：[1]广东省卫生防疫站预防医学门诊

出　　处：《广东医学》1995年第5期296-297,共2页Guangdong Medical Journal

摘　　要：１９９２年～１９９４年９月本门诊对被火等动物致伤者２１５５例进行组织培养人用狂犬疫苗（组苗）常规５针（０、３、７、１４、３０）和和单８针（０－６、３０天）法，每天肌注２ｍｌ以及按以上方法再分别联用抗狂犬病血清（抗血清）共４个组免疫后进行抗狂犬病毒抗体（抗－ＲＡ）测定。结果免疫后抗－ＲＡ总阳性率为７９．９０％（１７２２／２１５５），常规５针与５针联用抗血清间阳性率无差异（Ｘ２＝２．４　Ｐ＞０．０５）；单８针与８针联用抗血清组的阳性率也无差异（Ｘ２＝２．７９Ｐ＞０．０５）。因此若需用抗血清时可采用常规５针不必用８针法。Abstract We studied dmerent methods of immunizationfor 4 groups of patients Who were injured by robdent animals in total 2155 cases, among which twogroups of cases were treated with routinefive-injection and eight-injection of rabies vaccinewith antirabies serum respectively. Anti-RA wasdetected in the four groups after immunization.The result indicated that there was no significantdifference between the routine five injections andfive injections combined with antiserum, nosignificant difference btween the simpte three injections and the eight-injection combined Withantiserum.We can conclude that five injection ismore suitable than eight-injection when anti-RAserum is needed.

关 键 词：狂犬病疫苗 抗狂犬病血清 免疫效果 临床观察 

分 类 号：R512.99[医药卫生—内科学]