降解材料聚乳酸－聚乙二醇生物相容性的研究  

A Study on the Biocompatibility of Biodegradable PELA Copolymer

作　　者：王定国[1] 郑华[1] 胡颖嘉 邱书明 

机构地区：[1]四川省生物医学材料监测中心

出　　处：《北京生物医学工程》1995年第3期173-177,共5页Beijing Biomedical Engineering

基　　金：国家自然科学基金

摘　　要：作者对国产新型生物医用可降解材料ＤＬ—聚乳酸—聚乙二醇共聚物（ＰＥＬＡ）进行了系统的生物学评价。结果表明：降解材料ＰＥＬＡ无全身毒性、无热原和细胞毒性、无溶血（溶血率小于５％）、对皮肤和眼粘膜无刺激、不引起致敬反应、对骨髓多染红细胞无影响。体内植入２８０天，材料基本降解完全，材料周围纤维囊壁厚度逐渐变薄，炎症细胞反应减轻。因此，可认为降解材料ＰＥＬＡ有良好的生物相容性。A systemic biological evaluation was conducted for a new domestic biodegradable material PELA(Poly D.L-lactide-polyethyleneglycol copolymer).The results showed that PELA had no general toxicity,no reaction of pyrogen,no irritation to the skin and mucous membranes of eyes,no sensitization.The hamolysis rate was less than 5%.There was not effect to polychromatic erythrocyte of mouse bone marrow.The test of subchronic toxicity showed no pernicious effects to mice in one month.It was embedded under skin for nine months,the material degraded completely.As time elapsed,the fibrous cyst,which surrounded the embedded PELA,gradually became thinner,and the infective reaction decreased.Therefore,it may be concluded that the new biodegradable PELA has excellent biocompatibility.

关 键 词：降解材料 聚乳酸-聚乙二醇共聚物 生物相容性 

分 类 号：R318.08[医药卫生—生物医学工程]