苦瓜果对雄性大鼠生育力的影响  

Effects of Momordica Charantia Extract on Fertility of Male Rats

作　　者：覃国芳[1] 李远慧[1] 高晓勤[1] 牟肇龄 姜淑猷 鲍淑娟[1] 常凤岗[1] 陶必严[1] 

机构地区：[1]贵阳医学院组织胚胎学教研室,贵阳医学院药理学教研室,贵阳医学院植物化学教研室,贵阳医学院核医学教研室

出　　处：《贵阳医学院学报》1995年第1期14-17,共4页Journal of Guiyang Medical College

摘　　要：观察苦瓜果的不同成分对成年雄性大鼠生育力的影响。其中苦瓜粗制液可引起８３．４％的大鼠丧失生育力；附睾尾精子活力降低、畸形效增加；约７％～８％的曲细精管内易见多核巨细胞，并见晚期精子细胞有退变现象。停药２周后．生育力开始恢复，至第８周末已趋正常。表明苦瓜粗制液对雄性大鼠有较明显抗生育作用并具可逆性，而苦瓜提取物中的蛋白成分抗生育作用较差，非蛋白成分的作用极不明显。Momordica charantia linn, a plant species of the familly cucurbitaceae, contains various vitamins, amino acids and other chemical entities. Healthy adult Wistar rats, were divided into 4 groupe,among the experimental group A, were administered orally with the rough fruit extract of Momordica charania at a daily dose of 15 ml/kg(group B,for extract containing proteins, group C, for extract containing non-proteins) for 6 weeks. A marked reduction of sperm motility was observed with a concurrent increase of obnormal spermatozoa. There were various degrees of spermatogenic arrest mainly at the spermatid stage. The spermatids show degenerative change and formation of multinuclear giant cells were found in damaged tubules. The Morbhology of the Sertoli and Levdig cells did not change significantly,In comparison with the control, the Hematology, SGPT, BUN, plasma testosterome level were within the normal range, The infertility rate of the group A rats was found to be 83.4%(the group B rats was found to be 70.8%). It was concluded that the extract of Momordica charantia could cause infertility in male rats, mainly effecting maturation of sperm in the epididymis and the development of late stage spermatid. Fertility ability can be recovered completely 8 weeks after stopping medication

关 键 词：苦瓜 生育力 大鼠 雄性 避孕药 苦瓜籽 药理 

分 类 号：R979.21[医药卫生—药品]