蜂花粉对小鼠体内外脂质过氧化的影响  

EFFECT OF BEE POLLEN AND ITS ALCOHOL EXTRACT ON LIP1D PEROXIDATION IN VIVO AND IN VITRO

作　　者：钱伯初[1] 钱芸[1] 臧星星[1] 戚宝风 董文[2] 

机构地区：[1]浙江省医学科学院药物研究所 [2]浙江医科大学

出　　处：《营养学报》1989年第4期355-359,共5页Acta Nutrimenta Sinica

摘　　要：本文观察了蜂花粉及其醇提取物对小鼠体内外脂质过氧化的影响。结果表明,蜂花粉醇提物在体外能抑制正常小鼠肝匀浆过氧化脂质生成,并能对抗半胱氨酸和硫酸亚铁所致过氧化脂质生成增加。蜂花粉口服对老龄小鼠及由于四氧嘧啶与饲过氧化玉米油所致血清和肝组织过氧化脂质增加有明显的抑制作用。提示蜂花粉可能有益于维持体内自由基的动态平衡,保护机体免受过氧化脂质的侵害。The effect of bee pollen of Brassica campestris L. and its alcohol extract on lipid peroxidation was observed in vivo and in vitro.The results showed that the production of lipid peroxides in normal liver hotnogenate of mice and elevation of production of lipid peroxides induced by cysteine and FeSO4 in homogenate were found to be inhibited significantly by in vitro addition of alcohol extract of bee pollen.The elevation of lipid peroxides in serum and liver in adult mice induced by alloxan 75 mg/kg(iv)or by administration of peroxidized corn oil 0.2 ml/mouse was markedly inhibited by oral administration of bee pollen (10 g· kg-1·d-1)for 20 days as compared with respective control groups.The level of lipid peroxide in geriatric mice was also markedly lowered by oral administration of bee pollen (10 g·kg-1·d-1)for 3 months as compared to non-treated geriatric mice.Based on the above in vitro and in vivo experimental results, it may be suggested that bee pollen and its alcohol extract protect tissues against destruction by lipid peroxides.

关 键 词：蜂花粉 脂质过氧化 抗衰老 

分 类 号：R977.9[医药卫生—药品]