高血压与甘丙素的临床和基础研究  

A Clinical and Basic Study on the Relationship Between Hypertension and Galanin

作　　者：石湘芸[1] 赵云涛[1] 张兆馥 杨晔[1] 丁殿勋[1] 费宇行[1] 徐洪涛[1] 聂智群[1] 汤健[1] 张继峰[2] 唐朝枢[2] 

机构地区：[1]海军总医院心内科 [2]北京医科大学心肺内分泌室

出　　处：《海军总医院学报》1995年第1期1-3,共3页Journal of Naval General Hospital of PLA

摘　　要：用特异性放免法测定33例高血压患者血浆甘丙素(GAL)水平,结果显示高血压患者的血浆GAL水平(19.57±1.74Pg/ml)明显高于对照组(9.36±0.94Pg/ml,P<0.001)GAL与平均动脉压(MAP)呈正相关(P<O.05)GAL与内皮素(ET)呈正相关(P<O.001).自发性高血压大鼠(SHR)血浆GAL水平亦明显高于正常大鼠(P<0.001),GAL与MAP亦呈正相关(P<0.05),提示GAL是高血压的重要发病因素之一,体内多种多肽活性物质的增加,可能促进了高血压的发生与发展.The level of plasma galanin (GAL) was studied in 33 cases with hypertension andSHR (n=10)with radioimmunoassy. The results showed that plasma GAL level in patients withhypertension (19.57±1.74Pg/ml)was higher than that in normal subject (9.36±0. 94Pg/ml,P<0.001).A positive corrlation between plasma GAL and MAP (r=0.462,P<0.001). GAL andendothelin (ET) (r=0.790,P<0.01) was found. It was found that plasma GAL level elevatedsignificantly in SHR (P<0.01). A positive correlation between plasma GAL and MAP (r=0.543 ,P<0.05) was found. These data suggested that increase of plasma GAL may play an important role in the pathogenesis of hypertension.

关 键 词：高血压 甘丙素 研究 

分 类 号：R544.102[医药卫生—心血管疾病]