α－羰基烯酮环二硫代缩醛化学XXI：β，β－1，3－亚丙二硫基－α，β－不饱和酮与胍的缩合反应  

The Chemistry of α-Oxo Ketene Cyclic DithioacetalsXXI. The Preparation of Pyrimidines by the Condensation ofβ,β-(1,3-Propylene dithio)-α,β-unsaturated Ketones with Guanidine

作　　者：张殊佳[1] 刘群[1] 张长山 杨智蕴[1] 

机构地区：[1]东北师范大学化学系

出　　处：《合成化学》1995年第1期56-60,共5页Chinese Journal of Synthetic Chemistry

基　　金：国家教委优秀年轻教师基金资助项目

摘　　要：在乙醇为溶剂，乙醇钠为碱的条件下，标题类化合物归１ａ～ｃ，３ａ，４ａ与胍缩合反应生成相应的嘧啶类化合物２ａ～ｃ，３ｂ，３ｃ，４ｂ。在以ＤＭＦ为溶剂，乙醇钠为碱的条件下，化合物与胍反应可生成２－氨基－４－二甲氨基－６－苯基嘧啶２ａ’。该缩合反应的特点为标题类化合物与肌缩合生成嘧啶类化合物的同时，将乙氧基或二甲氨基引入嘧啶环的确定位置。为新的嘧啶类化合物。The title compounds and condense with guanidine to give pyrunidines in goodyields. The preduct structure is extremely dependent on the solvents used. Catalyzed by sodium ethoxide, thecorresponding pyrimidines and were obtained when ethanol served as the solvent;2-amino-4-dimethlyamino-6-phenylpyrimidine was produced when DMF applied. All these results expended theutility of the title compounds as a new intermediate in organic synthesis. In this paper, five new com-pounds and are first reported.

关 键 词：亚丙二硫基 酮 缩合反应 嘧啶类 

分 类 号：O631.5[理学—高分子化学] O626.41[理学—化学]