过敏性紫癜患儿血浆内皮素检测的意义  

THE DETERMINATION OF THE AMOUNT OF PLASMA ENDOTHELIN AND ITS CLINICAL SIGNIFICANCE IN CHILDREN WITH HENOCH-SCHONLEIN PURPURA

作　　者：赵金枝[1] 王同保[1] 贾秀云[1] 崔崇瑜[1] 张予华[1] 吕新华[1] 程巧玲[1] 

机构地区：[1]河南省人民医院儿科

出　　处：《河南医学研究》1995年第4期340-342,共3页Henan Medical Research

摘　　要：本文采用放射免疫法分别检测了２２例过敏性紫癜患儿和１９例正常儿童血浆内皮素浓度改变。其中单纯皮肤性紫癜７例，混合性紫癜８例，紫癜性肾炎７例。结果：单纯性紫癜血浆内皮素浓度为３７．３４±１４．０３ｐｇ／ｍｌ与对照组的３６．２３±１２．５１ｐｇ／ｍｌ比较无明显差异（Ｐ＞０．５０），混合型紫癜患儿血浆内皮素浓度为５３．１０±１４．５１ｐｇ／ｍｌ高于对照组和单纯紫癜组（Ｐ均＜０．０５），紫癜性肾炎血浆内皮素浓度明显增高达７７．７７±１２．４４ｐｇ／ｍｌ，显著高于对照组和单纯型与混合型紫癜患者（Ｐ均＜０．０１）。提示：血浆内皮素浓度增高与本病严重程度成正比，内皮素参与了混合性紫癜尤其是紫癜性肾炎发病过程。We detemined the amount of plasma endothelin of 19 health children and 22children with Henoch-Sch nlein purpura(HSP),in which the simple dermal purpura amount-ed to 7 patients; the mixed allergic purpura amonted to 8 patients;the purpura nephritisamounted to 7 patients. The results showed that the density of concentration of plasma en-dothelin in children with simple dermal purpura was 37.44±14.03 pg per milliliter,in com-parison with 36.23±12.51 pg per millliter of the controls there was no statistical difference(P>0.50):The endothelin value of 53.10±14.51 pg per milliliter plasma in patients withmixed allergic purpura was increased compared with the controls and the simple dermal pur-puras(P<0.05);The endothelin amount of per milliliter plasma, 77.77±12.44 pg in pa-tients with purpura nerphritis was significantly increased as compared with the controls andthe simple dermal and mixed allergic purpuras(P<0.01),The results indicate that the in-crease of the amount of plasma endothelin is parallet to the degree of illness in HSP patients,and that endothelin may be a factor of the pathogenetic process in mixed allergic purpura,es-pecially in purpura nephritis.

关 键 词：过敏性 紫癜 内皮素 血浆 儿童 

分 类 号：R725.546[医药卫生—儿科]