乳腺癌与良性增生组织铁蛋白放射免疫测定及免疫组化研究  

DETECTION OF FERRITIN IN BREAST CARCINOMA AND HYPERPLASTIC TISSUES BY RADIOIMMUNOASSAY AND IMMUNOHISTOCHEMISTRY

作　　者：李代强[1] 伍海南[1] 黄锦[1] 曹亦洪[1] 蔡季重 

机构地区：[1]湖南医科大学第二附属医院病理科,华盛顿大学人猿研究中心病理科

出　　处：《湖南医科大学学报》1995年第3期209-211,共3页Bulletin of Hunan Medical University

基　　金：美国国家癌症研究所/NIH科研基金

摘　　要：对４０例乳腺癌与癌旁组织铁蛋白作放免定量测定。同时，对２２例乳腺癌标本和３０例乳腺良性增生组织进行多种抗体的免疫组化观察。结果显示：乳腺癌组织铁蛋白含量均比癌旁组织、良性增生组织明显增高；含铁蛋白细胞主要为巨噬细胞。提示检测乳腺癌组织铁蛋白对明确诊断和估计预后有参考价值。ontents of ferritin were assayed by radioimmunoassay in 40 cases breast carcinoma tis-sues and the distribution of tissues ferritin was detected by immunohistochemical staining in22 cases of breast carcinoma and 30 cases of hyperplastic tissues. Results showed that thecontents of ferritin in breast carcinoma tissues were superior to non-carcinoma tissues ofbreast(P<0.01).The contents of ferritin were positively correlated with clinicostages ofthe tumor.Ferritin staining was detected mainly in cells of interstitial tissues surroundingneoplastic cells, These cells proved to be histocytes;Cells containing ferritin were also de-tected in neoplastic cells of 11 carcinoma cases(50%).Results suggest that riumbers of cellcontaining ferritin are important to distingnish between breast carcinoma and non-carcinomatissues. Contents of ferritin in breast carcinoma tissues may be a prognostic factor.

关 键 词：乳腺癌 乳腺疾病 放射免疫测定 免疫组化 

分 类 号：R655.8[医药卫生—外科学] R737.9[医药卫生—临床医学]