顺式（±）菊酸动力学拆分研究  

The Kinetic Resolution of d, 1-cis Chrysanthemic Acid

作　　者：钟民[1] 陈良[1] 

机构地区：[1]华东师范大学化学系

出　　处：《华东师范大学学报（自然科学版）》1995年第3期55-60,共6页Journal of East China Normal University(Natural Science)

摘　　要：本文研究了以（－）－ｔｒａｎｓ－２，２－二甲基－３－异丁烯基环丙烷甲醇为拆分剂对（±）－ｃｉｓ－２，２－二甲基－３－异丁烯基环丙烷羧酸（顺式（±）菊酸）的动力学拆分。研究表明此菊酸酯在２米，１０％ＤＣ－ＱＦ－１不锈钢色谱柱上可以得到完全分离。顺式（±）菊酸的两种立体异构体的酯化相对速率相差较大，本文研究了反应物比例，反应温度，反应时间对顺式（±）菊酸酯化产物的影响，选择较佳的反应条件，可以将顺式（±）菊酸的两种立体异构体分开。利用此反应对顺式（±）菊酸进行动力学拆分，获得（－）－顺式菊酸，其ｅ，ｅ值达９５％。Separation of the optical isomers of chrysanthemic acid has been carred out by gas chromatography. The diastereoisomeric esters of chrysanthemic acid with 1-trans chrysanthemol were separated on a column of 10% DC-QF-1 coated on Chromosorb W. The esterification speed of l-cis chrysanthemic acid with l-trans chrysanthemol was faster than that of d-cis chrysanthemic acid. According to it, the d, l-cis chrysanthemic acid has been resolved and l-cis chrysanthemic acid with 95% optical purity is obtained.

关 键 词：菊酸 动力学 拆分 除虫菊酯 杀虫剂 中间体 

分 类 号：TQ453.292[化学工程—农药化工]