环氧乙烷的遗传毒性研究──Ⅵ小鼠骨髓多染红细胞微核试验  

Genotoxicity Study of Ethylene Oxide Ⅵ Micronucleus Test of Polychromatic Erythrocytes of Bone Marrow in Mice

作　　者：钟坤[1] 张龄[1] 夏国兴[1] 陆静芬[1] 董元烨 

机构地区：[1]上海职工医学院,华东师范大学生物学系

出　　处：《华东师范大学学报（自然科学版）》1995年第4期97-100,共4页Journal of East China Normal University(Natural Science)

摘　　要：应用骨髓多染红细胞微核试验研究了环氧乙烷（ｅｔｈｙｌｅｎｅｏｘｉｄｅ，Ｅｔｏ）的遗传毒性作用。本研究通过亚急性及亚慢性二种方法对Ｅｔｏ的毒性进行了检测。通过实验证明Ｅｔｏ在亚急性条件下，染毒组与对照组比较微核率呈现出极显著的差异。在亚慢性实验条件下，染毒组与对照组比较微核率也呈现极显著差异，说明环氧乙烷确是一个有效的诱变剂。Using the micronucleus testing for polychromatic erythrocytes of bone marrow in mice, the function of genotoxicity of ethylene oxide (Eto) was studied. The genotoxicity of Eto was tested with subacute and subchronic tests. According to these experiments, there was significant difference on the frequency of micronuclues between the experimental and control groups in subacute test. In addition in subchronic test there was significant difference too. The results indicated that Eto was an effective mutagen.

关 键 词：环氧乙烷 骨髓多染红细胞 微核率 遗传毒性 

分 类 号：Q319.33[生物学—遗传学] R994.3[医药卫生—毒理学]