蚓激酶的诱变实验研究  

STUDY ON MUTAGENICITY OF FIBRINOLYTIC PROTEASES FROM EARTHWORM

作　　者：胡火珍[1] 潘克俭[1] 邢一玲[1] 杨英[1] 陶大昌[1] 郑雪莲[1] 杨正苑 

机构地区：[1]华西医科大学医学细胞生物学教研室,华西医科大学药学院

出　　处：《华西药学杂志》1995年第3期132-135,共4页West China Journal of Pharmaceutical Sciences

摘　　要：用鼠伤寒沙门氏菌回复突变试验，小鼠骨髓红细胞微核试验及ＣＨＬ细胞染色体畸变试验，对蚓激酶进行了诱变性试验研究，结果表明鼠伤寒沙门氏菌回复突变试验为阴性，该药可能不诱发基因突变；小鼠骨髓红细胞微核试验及ＣＨＬ细胞染色体畸变试验均为阴性，说明该药可能不诱发体内、体外遗传物质损伤作用。The mutagenicity of fibrinolytic proteases from earthworm was studied by Ames test,micronucleus test of NIH mouse bone marrow and chromosome assay in CHL cell. Negative results were obtained, which suggested that earthworm kallikin did not induce prokaryotic cell gene mutation or chromosome damage both in vitro and in vivo.

关 键 词：抗凝血药 蚓激酶 诱变性 染色体畸变试验 

分 类 号：R973.2[医药卫生—药品] R965.3[医药卫生—药学]