银杏苦内酯B降低低氧性肺动脉高压的研究  

Effects of Ginkgolide B on Isobaric Hypoxic Pulmonary Hypertension in Rats

作　　者：程德云 陈文彬 

出　　处：《华西医科大学学报》1995年第4期386-390,共5页Journal of West China University of Medical Sciences

基　　金：高等学校博士学科点专项基金;纽约中华医学基金

摘　　要：分别以银杏苦内酯以Ｂ（ＢＮ５２０２１）、低氧、低氧加ＢＮ５２０２１处理Ｗｉｓｔａｒ大鼠，另设对照，观察特异性血小板激活因子（ＰＡＦ）受体拮抗剂ＢＮ５２０２１对低氧性肺动脉高压的作用。结果显示：ＢＮ５２０２１对正常大鼠肺血流动力学无明显影响；低氧３周后大鼠肺动脉平均压（４．０５±０．５６ｋＰａ）及肺血管阻力（９６５２±１４９０ｋＰａ·ｓ／Ｌ）明显高于对照组（２．２２±０．２４ｋＰａ及２５７８±７０４ｋＰａ·ｓ／Ｌ）．并发生右心室肥厚和肺血管重建；用ＢＮ５２０２１后可明显减轻低氧所致的上述改变（肺动脉平均压为２．９７±０．３３ｋＰａ）。以上结果提示：ＰＡＦ在低氧性肺动脉高压和肺血管重建过程中起一定的作用，而某些ＰＡＦ拮抗剂有可能成为防治低氧性肺动脉高压的新药。t We examined the effects of ginkgolideB(BN52021),a specific platelet activating factor(PAF)antagonist,on hypoxia-induced pulmonary hy-pertension and pulmonary vascular remodeling. Chronic hypoxia can cause pulmonary hypertensionand pulmonary vascular remodeling in rats. Treatedwith BN52021,the rat’s pulmonary hypertension,pulmonary vascular remodeling and right ventricularhypertrophy at 3 weeks of hypoxic exposure(FiO_2=0.10)could be reduced.The results suggest that PAFcontributes to the development of chronic hypoxic pul- monary hypertension and pulmonary vascular remodel- ing, and PAF antagonist may be an useful agent forpreventing hypoxic pulmonary hypertension.

关 键 词：银杏苦内酯B 低氧血症 肺动脉高血压 

分 类 号：R543.205[医药卫生—心血管疾病] R285.5[医药卫生—内科学]