Weiss反应及其在有机合成中的进展  

Weiss reaction and its advance in organic synthesis

作　　者：潘东[1] 杨世柱[1] 

机构地区：[1]华南师范大学化学系

出　　处：《化学试剂》1995年第4期217-221,共5页Chemical Reagents

摘　　要：两分子二甲基－３－氧－戊二酸酯和一分子乙二醛在水溶液中反应可生成顺式双环［３．３．０］辛烷－３，７－二酮－２，４，６，８－四羧酸酯。这一反应即称Ｗｅｉｓｓ反应。该反应条件温和，操作简便，产物立体选择性高，是一正为有机合成化学家重视的新型有机反应。它广泛应用于合成含双环［３．３．０］辛烷体系的化合物及含顺式环戊烷体系的化合物。为一些难于合成的大张力有机化合物，复杂的多环化合物，甚至为甾族化合物的全合成提供了一条新的、方便的途径。The reaction of 2 mol dimethyl-3-oxo-glutarate with 1 mol glyoxal to give cis-bicyclo [3. 3. 0]octane-3, 7-dione-2, 4, 6, 8-tetracarboxylate in water solution is called Weiss reaction. The reaction is easy to be carried out and proceeds under mild conditions to give good stereoselective compounds. It is a new kind of organic reaction which is being valued by organic chemists. This reaction can be used to synthesize cis-bicyclo [3, 3, 0]octane system and cis-cyclopentane system, such as tension cyclic com ponds, complex polycyclopeutane compounds and steroids.

关 键 词：Weiss反应 环烷烃 环稀烃 合成 多环化合物 

分 类 号：O621.263[理学—有机化学]