酸碱失衡狗脑脊液的主要离子变化  

Strong Ions Composition of Cerebrospinal Fluid in Dogs with Acute Acid-Base Disorders

作　　者：金发光[1] 钱桂生[1] 邵丽丽[1] 赵自强[1] 

机构地区：[1]重庆第三军医大学新桥医院全军呼吸中心,西安四军大唐都医院呼吸内科

出　　处：《基础医学与临床》1995年第2期56-59,共4页Basic and Clinical Medicine

摘　　要：本研究复制了４组狗酸碱失衡的动物模型，（１）正常碳酸血症代谢性酸中毒；（２）正常碳酸血症代谢性碱中毒；（３）呼吸性酸中毒；（４）呼吸性碱中毒。动态观察动脉血和ＣＳＦ的酸碱变量及主要离子值。尽管４组动脉血酸碱变量及主要离子值均发生显著改变，但ＣＳＦ［Ｎａ￣＋］、［Ｋ￣＋］、［Ｌａｃｔ］及Ｏｓｍ均无明显改变，［Ｃｌ￣－］ｃｓＦ却与［ＨＣＯ￣－＿３］ｃｓＦ发生等量互逆改变。结果说明ＨＣＯ￣－＿３／Ｃｌ￣－的等量交换在酸碱失衡狗ＣＳＦ的酸碱调节中有一定作用。trong ions composition of CSF was measured during 6 hours of acute acid base disorders inanesthetized dogs. Four groups of dogs were studied:(1) isocapnic metabolic acidosis;(2)isocap-nic metabolic alkalosis;(3)acute respiratory acidosis; and(4)acute respiratory alkalosis. CSF Na￣+,K￣ +,lactic acid concentration and osmolality remained unchanged with almost iden-tical reciprocal changes in CSF concentration of Cl￣- and HCO￣-_3 during the acid-base disorders de-spite significant changes in plasma[K￣+],PCO_2,[HCO￣-_3],and pH. It is belived that the HCO￣ -_3/Cl￣- exchange may play an important role in CSF acid-base regulation in acid-base disorders.

关 键 词：脑脊液 酸碱平衡紊乱 狗 动物模型 

分 类 号：R589.604[医药卫生—内分泌]