左旋硝基精氨酸诱导大鼠持续性高血压  

NG-Nitro-L-Arginine Induces Sustained Hypertension in Rats

作　　者：高连如[1] 赵云涛[1] 石湘芸[1] 熊监然 杨晔[1] 刘国仗[1] 张继峰[1] 田青[1] 唐朝枢[1] 汤健[1] 

机构地区：[1]海军总医院心内科,阜外医院高血压研究室,北京医科大学心肺内分泌研究室

出　　处：《基础医学与临床》1995年第3期49-53,共5页Basic and Clinical Medicine

摘　　要：为了探索ＥＤＲＦ合成拮抗剂──左旋硝基精氨酸（Ｎ￣Ｇ－Ｎｉｔｒｏ－Ｌ－Ａｒｇｉｎｉｎｅ，Ｌ－ＮＮＡ）能否诱导大鼠产生持续性高血压，本实验动态测定Ｗｉｓｔａｒ大鼠应用Ｌ－ＮＮＡ后血压、心率、心脏重量，主动脉环反应性变化，组织及血浆生化改变。结果表明，应用Ｌ－ＮＮＡ的各组血压均逐渐明显升高；心率在第七天开始减慢，至２８天时减慢最显著，此时心脏绝对重量也明显增加；主动脉环对ＮＥ、ＥＴ收缩反应明显增强，对Ａｃｈ舒张反应明显减低，组织ｃＧＭＰ明显减低，组织及血浆ＥＴ明显增高，血浆ＰＲＡ、ＡＧＴⅡ明显减低，血浆ＭＤＡ明显增高。o explore whether prolonge administration of N￣ g-Nitro-L-Arginine(L-NNA ) can inducesustained hypertension in rats. We divied thirty female Wistar rats into five groups according tothe duration of L-NNA treatment.L-NNA may induced significant hypertension in all rats. Bloodpressure was much higher in all treated groups than that in control group(P<0.01).Heart ratesreduced at 1d and reduced significantly at 28d. Increase in heart weight was found in 28d group.Maximal constricting responses of aortic rings to ET and NE were significantly augmented anddose-dependent relaxation by Ach decreased markedly. The ET levels of plasma and tissue fromaoriic strip werc heigher and cGMP levels of aortic tissue were lower.Plasma AGT Ⅱand PRAwere reduced. Plasma MDA was increased.

关 键 词：精氨酸 高血压 鼠 病因 

分 类 号：R544.102[医药卫生—心血管疾病]