苯海索对豚鼠乳头状肌动作电位、收缩力及兔窦房结细胞动作电位的影响  

Effects of Trihexyphenidyl on Action Potentials-contractility in Guinea

作　　者：姜波[1] 宋秀媛[1] 张贵卿[1] 可君[1] 

机构地区：[1]潍坊医学院心血管药物研究室,河南医科大学药理教研室

出　　处：《基础医学与临床》1995年第6期50-53,共4页Basic and Clinical Medicine

摘　　要：苯海索（ＴＨＰ）１０、５０、１００μｍｏｌ／Ｌ抑制豚鼠乳头状肌收缩力（Ｆｃ），缩短动作电位时程（ＡＰＤ）和有效不应期（ＥＲＰ），抑制最大去极化速率（Ｖｍａｘ）；ＴＨＰ５０μｍｏｌ／Ｌ对Ｖｍａｘ的抑制呈频率依赖性。ＴＨＰ５０、１００μｍｏｌ／Ｌ可降低其ＡＰＡ，缩短其ＥＲＰ，ＴＨＰ可对抗ＢａｙＫ８６４４增强Ｆｃ，延长ＥＲＰ、ＡＰＤ的作用。ＴＨＰ５０μｍｏｌ／Ｌ可抑制哇巴因（Ｏｕａ）诱发的振荡电位和触发活动。ＴＨＰ５、１０、５０μｍｏｌ／Ｌ抑制兔窦房结细胞动作电位的动作电位幅度（ＡＰＡ），４相除极化速率（ＳＰ＿４）和Ｖｍａｘ，延长窦性周氏（ＳＣＬ）。结果提示ＴＨＰ对Ｃａ￣（２＋）和Ｎａ￣（２＋）的跨膜转运均有抑制作用。y Synchronous recordings of action potentials(AP)and contractile force(Fc)of isolatedguinea pig papillary muscles trihexyphenidyl(THP)1 0,50,100 μmol/L markedly depressed theFc,ampitudes of the action potentials (APA),and maximal upstroke velocity(Vmax),shortenedthe action potentials duration(APD)and effective refractory period(ERP ),but had no effect onthe duration of phase 3(DP_3).The inhibitory effect of THP 50μmol/L on Vmax was frequencydependent.The increase in contractile force and prolongation of APD,ERP caused by Bay K 8644were abolished by THP 10 μmol/L. THP 50 μmol/L also abolished the oscillatory potentials andtriggered activity induced by ouabain(0ua).THP 5,10,50μmol/L depressed the slope of phase 4(SP_4),Vmax,APA,and prolonged the spontaneous sinus cycle length(SCL)on the action poten-tials of dominant pacemaker cells in sinoatrial nodes of rabbits.The results suggest that THP mayinhibit the influx of Ca￣(2+)and Na￣+in cardiac cells.

关 键 词：苯海索 乳头状肌 动作电位 收缩力 窦房结 

分 类 号：R971.92[医药卫生—药品] R972[医药卫生—药学]