阴道栓剂治疗阴道毛滴虫感染小鼠的实验研究  

STUDIES ON THE EFFECT OF VAGINA SUPPOSITORY AGAINST TRICHOMONAS VAGINALIS IN MICE

作　　者：方菁[1] 吴少廷[1] 冯友仁[1] 周梓林[1] 

机构地区：[1]湖北省医学科学院寄生虫病研究所,同济医科大学寄生虫学教研室

出　　处：《寄生虫与医学昆虫学报》1995年第1期6-8,共3页Acta Parasitologica et Medica Entomologica Sinica

摘　　要：本实验以小白鼠为实验动物，作阴道毛病虫感染的动物模型，对阴道栓剂抗鼠体内阴道毛滴虫疗效进行了研究，实验分：配伍栓剂组、甲硝唑原粉组、环丙沙星原粉组和１％ＳＣＣ对照组。感染后２４ｈ采用一次性灌胃给药，１０ｄ后解剖小鼠，观察脓肿形成及愈合，镜检腹水和脓液。结果显示：栓剂治疗组滴虫清除率为５０％和９０％时，其剂量低于甲硝唑原份治疗剂量，两者比较具有显著性差异（Ｐ＜０．０５），而栓剂中杀淋球菌药环丙沙星原粉单独使用不能杀灭阴道毛滴虫。可见，甲硝唑与环丙沙星联合应用产生了一定的协同作用，减少了甲硝唑原粉杀滴虫的用量。The therapeulic effect against Trichomonas vaginalis with vagina suppository in mice was studied. The experiments were divided into four groups including metronidazole and ciprofloxacin compound, metronidazole TC, ciprofloxacin TC and 1% SCC as the control. 24 hours after infection, the mice were orally given durgs.10 days later, all mice were dissected to examine the number and size of the abscess, the pus and the ascites were then examined fori T. vaginalis. The experiments showed that when the eliminative rate were 50 % and 90 %, the dosage of metronidazole in suppository was lower than that of metronidazole TC(p<0.05). The ciprofloxacin has no effect against Trichomonas vaginalis when used alone. The results indicated that a coordinative effect was existed when metronidazole and ciprofloxacin compounds were used jointly.

关 键 词：阴道毛滴虫 感染 动物模型 阴道栓剂 疗效 

分 类 号：R711.310.5[医药卫生—妇产科学] R978.61[医药卫生—临床医学]