胃肠道生物黏附给药系统研究进展  

Gastrointestinal bioadhesion drug delivery system

作　　者：裘建成[1] 高永良[1] 

机构地区：[1]军事医学科学院毒物药物研究所,北京100850

出　　处：《中国新药杂志》2005年第7期830-834,共5页Chinese Journal of New Drugs

摘　　要：胃肠道生物黏附给药系统(GBDDS)是指利用聚合物与胃、肠黏膜黏液层/上层细胞表面之间的生物黏附,延长药物制剂在胃肠道停留时间或特定部位作用时间的给药系统,在缓控释给药系统中占重要地位。现对胃肠道生物黏附作用的机制、影响因素、生物黏附材料的种类和生物黏附制剂的体内外评价方法进行综述,旨在为研究开发新型口服给药系统提供新的思路和方法。Gastrointestinal bioadhesion drug delivery system （GBDDS） can be described as a drug delivery system that make use of the attachmentbetween the mucus layer/the epithelial cell layer and mucoadhesive polymer to prolong the action time of pharmaceutical in gastrointestinal or some specific site, which plays an important part in the development of sustained/controlled release drug delivery system. This paper reviews the background, principles and potential application of GBDDS as an oral drug delivery vehicle, providing the strategy and rationale that further investigations may be required.

关 键 词：胃肠道生物黏附给药系统 黏膜黏附 细胞黏附 聚合物 

分 类 号：R944.9[医药卫生—药剂学] R975[医药卫生—药学]