胰酶胶囊与多酶片对照治疗非胰腺疾病伴消化不良症状的疗效  

Effects of pancreatin capsules versus multienzyme tablets in the treatment of non-pancreatic diseases with dyspepsia

作　　者：徐雷鸣[1] 宗春华[1] 张敏红[1] 桑玉尔[1] 董国芳[1] 刘清华[1] 

机构地区：[1]上海第二医科大学附属新华医院消化内科,上海200092

出　　处：《中国新药杂志》2005年第7期914-916,共3页Chinese Journal of New Drugs

摘　　要：目的:比较胰酶胶囊与多酶片治疗非胰腺疾病伴消化不良患者的疗效。方法:将116例随机分成两组,胰酶胶囊组56例,给予胰酶胶囊2粒,po,tid;多酶片组60例,给予多酶片5片,po,tid;两组疗程均为4周。服药后2,4周进行临床症状的积分评价。结果:胰酶胶囊组治疗4周后在腹痛、饱胀、胃肠胀气、腹泻等积分分别下降了(1·06±0·16),(1·40±0·25),(1·48±0·27),(1·16±0·18)分;多酶片组分别下降了(0·18±0·05),(0·43±0·09),(0·48±0·13),(0·21±0·04)分。两组比较差异均有非常显著性(P<0·01)。治疗4周后胰酶胶囊组总有效率为93%,多酶片组为58%,两组间比较差异有非常显著性(P<0·01)。结论:胰酶胶囊治疗非胰腺疾病伴消化不良的疗效优于多酶片。Objective：To compare the efficacy of pancreatin capsules with multienzyme tablets in the treatment of non-pancreatic diseases with dyspepsia. Methods ： 116 patients with non-pancreatic diseases with dyspepsia were randomized orally to receive either pancreatin capsules （300 mg, n = 56）, or multienzyme tablets （400 mg, n = 60） three time a day for 4 weeks. The clinical symptoms scores were used to evaluate the clinical responses to both treatment groups before and in the week 2 and 4 after the therapy. Results：The reductions of clinical cumulative scores of abdominal pain, sensation of fullness, abdominal distending and diarrhea in the pancreatin group versus multienzyme group were （1.06 ± 0.16）, （1.40 ± 0.25）, （1.48 ±0.27）, （ 1.16 ± 0.18） versus （0.18 ± 0.05）, （0.43 ± 0.09）, （0.48 ± 0.13）, （0.21 ± 0.04）, respectively, at the end of the therapeutic course （P 〈 0.01 ）. The overall efficacy rate of the pancreatin and multienzyme therapy were 93% and 58%, respectively （P 〈 0.01 ）. Conclusion： Superiority of pancreatin capsules to multienzyme tablets in the treatment of non-pancreatic diseases with dyspepsia is evident.

关 键 词：胰酶胶囊 非胰腺疾病 消化不良 多酶片 

分 类 号：R975.1[医药卫生—药品] R969.4[医药卫生—药学]