氯诺昔康与吗啡用于开胸手术后患者自控镇痛的比较  

Efficacy of patient-controlled analgesia with morphine versus lornoxicam for the pain relief in patients undergoing thoracotomy

作　　者：俞莹芳[1] 谢致[1] 梁伟民[1] 

机构地区：[1]复旦大学附属华山医院麻醉科,上海200040

出　　处：《中国新药杂志》2005年第7期921-923,共3页Chinese Journal of New Drugs

摘　　要：目的:在肋间神经阻滞的基础上,比较氯诺昔康与吗啡用于开胸手术后患者自控镇痛的疗效及不良反应。方法:择期行开胸手术的患者35例,术前均行肋间神经阻滞,术后随机双盲分为两组,给予患者自控镇痛:M组给予吗啡0·5mg·mL-1+氟哌利多0·02mg·mL-1,L组给予氯诺昔康0·32mg·mL-1+氟哌利多0·02mg·mL-1。镇痛效果评价采用VAS评分。结果:两组患者术后各时段的VAS评分无显著性差异,而不良反应的发生率L组明显少于M组。结论:在术前肋间神经阻滞的基础上,通过PCA系统静脉输注氯诺昔康,也能提供开胸手术后满意的镇痛治疗,疗效与吗啡相似。Objective： To evaluate the efficacy and safety of lonorxicam versus morphine for patients controlled analgesia（PCA） in patients undergoing thoracotomy. Methods ： A prospective, randomized, doubleblind clinical study recruited 35 patients undergoing elective thoracotomy, who received the preincisional intercostal nerve block prior to the surgery, and were randomly i.v. administered with either morphine （0.5mg· mL^-1, n = 18） or lonorxicam （0.32 mg· mL^-1, n = 17） post surgery. Efficacy of the pain relief was assessed using a visual analogue scale. Results：No statistical difference in the analgesic effects was found between both groups. The lornoxicam patients had fewer incidences of adverse events than the morphine patients. Conclusion： Lornoxicam offers an alternative to morphine for the paitents controlled analgesia in patients with thoracotomy.

关 键 词：术后镇痛 氯诺昔康 吗啡 肋间神经阻滞 开胸手术 

分 类 号：R971.1[医药卫生—药品] R969.4[医药卫生—药学]