回生丸的脱毒药效学评价  

EVALUATION ON DETOXIFICATION EFFECT OF HUISHENG PILL

作　　者：何蕾[1] 崔艳英[1] 陈素青[1] 朱蓉[1] 宁亚清[1] 潘励山[1] 

机构地区：[1]北京大学中国药物依赖性研究所,北京100083

出　　处：《中国药物依赖性杂志》2005年第3期190-193,共4页Chinese Journal of Drug Dependence

摘　　要：目的:评价回生丸的脱毒药效学。方法:采用剂量递增法建立吗啡依赖大鼠催促戒断模型、吗啡依赖大鼠自然戒断模型以及吗啡依赖猴自然戒断模型,然后给予回生丸进行治疗。结果:回生丸2·88、5·76g·kg-1两个剂量可显著降低吗啡依赖大鼠催促戒断症状的分值(P<0·05),但对体重下降的抑制不明显(P>0·05);回生丸和可乐定均不能控制吗啡依赖大鼠自然戒断的体重下降(P>0·05);回生丸3·2、6·4g·kg-1两个剂量均能在不同程度上控制吗啡依赖猴自然戒断的戒断症状,抑制体重下降(P<0·05或P<0·01)。结论:回生丸对吗啡依赖动物的戒断反应表现出明显的抑制作用。Objective： To evaluate the detoxification effect of Huisheng pill. Methods： Models of morphine- dependent rats and monkeys were established by dose- increasing administration. After precipitated by naloxone or natural withdrawal, the abstinent syndromes and weight loss of addictive rats and monkey swere observed.Results ： Huisheng pills 2.88 and 5.76 g·kg^-1 significantly decreased the score of withdrawal syndromes （ P 〈 0.05） but did not control the weight loss （ P 〉 0.05 ） on the rat models of withdrawal test. Neither Huisheng pills nor clonidine controlled the weight loss（ P 〉 0.05） on the rat models of withdrawal test. Huisheng pills 3.2 and 6.4 g· kg^-1 controlled the withdrawal syndromes and inhibited the weight loss of monkeys （ P 〈 0.05 or P 〈 0.01 ）. Conclusion ： Huisheng pills show a significant detoxification effect on models of morphine- dependent rats and monkeys.

关 键 词：回生丸 脱毒药效学 评价 吗啡依赖 

分 类 号：R595.5[医药卫生—内科学]