左旋四氢巴马汀对可卡因泛化甲基苯丙胺效应的影响  

EFFECTS OF l-THP ON COCAINE GENERALIZATION TO METHAMPHETAMINE

作　　者：王燕波[1] 任燕华[1] 郑继旺[1] 

机构地区：[1]北京大学中国药物依赖性研究所,北京100083

出　　处：《中国药物依赖性杂志》2005年第3期193-196,共4页Chinese Journal of Drug Dependence

基　　金：国家重点基础研究项目资助(课题编号:2003CB515400)

摘　　要：目的:了解不同剂量的左旋四氢巴马汀(l-THP)对成瘾药物精神依赖性的影响。方法:用固定比强化方法使大鼠对可卡因(10·00mg·kg-1)形成稳定的辨别行为。以不同剂量的l-THP(0·63、1·25、2·50、5·00mg·kg-1)或甲基苯丙胺(MA)(0·03、0·06、0·13、0·25mg·kg-1)替代训练剂量的可卡因;以l-THP拮抗可卡因的泛化效应,并与D1和D2受体拮抗剂SCH23390和雷可必利的效应对照。结果:10·00mg·kg-1剂量的可卡因能使大鼠形成稳定的辨别行为;训练剂量的可卡因不能泛化本实验所使用的任何一种剂量的l-THP,但可泛化0·25mg·kg-1以上剂量的MA。SCH23390、雷可必利和l-THP均可显著减弱可卡因对MA的泛化效应。结论:在本实验系统中,可卡因可使大鼠形成稳定的辨别效应;可卡因能泛化MA;DA受体参与调控这种泛化效应,l-THP能显著降低可卡因泛化MA的效应表明它能降低MA精神依赖性的形成。Objective： To explore the effects of 1-tetrahydmpalmatine（1 - THP） on drugs with psychic dependence producing potential. Methods： Rats were trained to discriminate cocaine（10.00 mg·kg^-1） from saline under fixed - ratio schedule. After discrimination was established, 1- THP（0.63,1.25,2.50 and 5.00 mg·kg^-1 ）or methamphetamine （MA,0.03,0.06,0.13 and 0.25mg·kg^-1） at different doses were given to substitute for cocaine of training dose; then, the rats were administered with DA receptor antagonists SCH23390 or raclopride or 1 - THP prior to the injection of MA at different doses to antagonize the effect. Results ：The rats acquired disc6mination of cocaine from saline. Any dose of 1 - THP used failed to substitute for cocaine of training dose, while MA at the dose equal to or higher than 0.25 mg·kg^-1 did. Such generalization effect was attenuated by SCH23390, raclopride and 5.00 mg·kg^-1 1-THP significantly. Conclusion： Rats can steadily discriminate cocaine from saline; cocaine of training dose can generalize MA. DA receptors are involved in this effect. The effect of 1- THP on cocaine generalization to MA suggests that 1- THP can decrease the psychic dependence of MA.

关 键 词：左旋四氢巴马汀 可卡因 甲基苯丙胺 精神依赖性 

分 类 号：R595.5[医药卫生—内科学]