参麦活血饮对糖尿病大鼠早期周围神经病变的作用  

Effects of Shenmai Huoxue Decoction on early diabetic peripheral neuropathy in rats

作　　者：薛红丽[1] 王文健[1] 陈剑秋[1] 

机构地区：[1]复旦大学附属华山医院中西医结合研究所,上海200040

出　　处：《中西医结合学报》2005年第1期31-34,共4页Journal of Chinese Integrative Medicine

基　　金：国家教委高校博士点科研基金资助项目 (No .2 0 0 0 4 3)

摘　　要：目的 :观察参麦活血饮对糖尿病大鼠感觉神经传导速度 (sensorynerveconductionvelocity ,SNCV)及红细胞醛糖还原酶 (aldosereductase ,AR)活性和血浆内皮素 (endothelin ,ET)水平的影响 ,探讨其作用的可能机制。方法 :采用链脲佐菌素 (streptozotocin ,STZ)诱发糖尿病大鼠模型 ,造模 1周后用参麦活血饮治疗 ,用药 4周后测定SNCV及红细胞AR活性和血浆ET水平。结果 :糖尿病大鼠SNCV减慢 ,波幅减小 ,潜伏期延长 ,红细胞AR活性和血浆ET水平升高 ,与正常组相比差异显著 (P <0 .0 5 ) ;参麦活血饮治疗组上述改变减轻 ,与糖尿病模型组相比差异显著 (P <0 .0 5 )。结论 :参麦活血饮有防治糖尿病大鼠早期周围神经病变的作用 。Objective： To evaluate the effects of Shenmai Huoxue Decoction （SMHXD） on early diabetic peripheral neuropathy （DPN） in rats. Methods： The rats were randomly divided into 3 groups： normal group,diabetic model group and SMHXD-treated diabetic group. The diabetic rats were induced by streptozotocin（STZ） intraperitoneally. After the treatment, sensory nerve conduction velocity （SNCV） of caudal nerve was detected with evoked electromyography, and the activity of aldose reductase （AR） in erythrocytes and the concentration of endothelin （ET） in plasma were measured. Results： It was showed that the SNCV reduced significantly and the activity of AR in erythrocytes and the concentration of ET in plasma were increased significantly in diabetic group as compared with those in the normal group. The SNCV was increased, and the activity of AR in erythrocytes and the concentration of ET in plasma were improved significantly in SMHXD-treated diabetic group after the treatment. Conclusion： The results indicate that SMHXD can alleviate the lesion of DPN in the early stage of diabetic rats.

关 键 词：参麦活血饮 糖尿病神经病变 动物 实验 

分 类 号：R285[医药卫生—中药学]