盐酸吗啉脒胍的合成研究  

Study on the synthesis of moroxydine hydrochloride

作　　者：魏文珑[1] 常宏宏[1] 王利珍[1] 王志忠[1] 

机构地区：[1]太原理工大学 化学化工学院,山西太原030024

出　　处：《应用化工》2005年第7期433-434,439,共3页Applied Chemical Industry

摘　　要：以吗啉和盐酸为原料合成盐酸吗啉,使其与双氰胺反应制备盐酸吗啉脒胍。重点讨论了原料配比、加料顺序、反应时间及溶剂等因素对合成工艺的影响。研究表明：吗啉：浓盐酸=1．06∶1(摩尔比),合成盐酸吗啉的收率可达98．27％,且加料顺序对反应无明显影响；以二甲苯为溶剂,盐酸吗啉：双氰胺=0．8∶1(质量比),反应时间为3．5h,盐酸吗啉脒胍的收率为97．01％。两步反应总收率可达96．97％。Morpholine hydrochloride was synthesized from morpholine and hydrochloric acid, then reacted with dicyandiamide, and obtained moroxydine hydrochloride. The influence of mixture ratio, feeding order,reaction time and solvent on synthesis process were studied. It was shown that, n （morpholine） ： n （ concentrated hydrochloric acid） = 1.06： 1, the yield of morpholine hydrochloride can be reached 98.27%,there was no evident influence on added materials sequence. The solvent is dimethyl benzene, m（ morpholine hydrochloride） ： m（cyanoguanidine） = 0.8： 1, and the reaction time is 3.5 h, the yield of moroxydine hydrochloride can be reached 97.01%. The yield of two process can be reached 96.97%.

关 键 词：吗啉 盐酸吗啉 盐酸吗啉脒胍 合成 

分 类 号：TQ46[化学工程—制药化工]