藏花红合成研究  

Study on synthesis of saframine O

作　　者：李陶琦[1] 潘清[1] 

机构地区：[1]西安近代化学研究所,陕西西安710065

出　　处：《应用化工》2005年第7期437-439,共3页Applied Chemical Industry

摘　　要：研究了以邻甲基苯胺为起始原料,经重氮化、偶合、还原、氧化反应合成藏花红的方法。讨论了反应条件对反应收率的影响。在重氮化反应：-6～-1℃,2h；偶合反应：33-35℃,3h；还原反应：95℃,6h；氧化反应：98-102℃,4h时,藏花红得率达到73．87％。Synthesize saframine O using o-toluidine as primer reactant by diazotization, coupling reaction,reduction reaction, and oxidation. It was found that the yield of saframine O was up to 73.87% under a definite condition. The condition were as follows：diazotization is 2 h, -6 - - 1℃ ;coupling reaction is 3h, 33 -35℃ ;reduction reaction is 6 h, 95℃ ;oxidation reaction is 4 h, 98 - 102℃.

关 键 词：藏花红 邻甲基苯胺 重氮化偶合反应 还原反应 氧化 

分 类 号：O625.65[理学—有机化学]