糖尿病周围神经病变的机制及康络素对其疗效的观察  

Mechanism of peripheral neurol pathological changes and observation of curative effects of cronassial in diabetes millitus

作　　者：郭军[1] 王秀梅[1] 张建华[1] 王维忱 柴国录 

机构地区：[1]佳木斯医学院第一附院内分泌科

出　　处：《佳木斯医学院学报》1995年第5期43-44,共2页

摘　　要：本文从代谢障碍方面探讨了糖尿病周围神经病变的发生机制,认为糖尿病周围神经病变是由于葡萄糖的活化障碍及脂肪代谢障碍引起,包括山梨醇旁路代谢增强,肌醇代谢障碍。并观察了康络素能促进神经的生长,使神经细胞功能早日恢复;它能进入细胞膜,使胞膜上的 Na^+—K^+—ATP 酶活化;还具有周围神经镇痛作用。The pathogensis of peripheral neural pathological changes in diabetes mellitus was studied from aspect of metabolic dysfunction.It was considered that the perpheral neural pathological changes in diabetes mellitus was caused by glucose activation dysfunction and fat metabolic dys- function,including metabolize strengthening of sorbitol path way and metabolic dysfunction of in- ositol.The curative effects in diabetes mellitus.Results were observed,suggesting it was very ef- fective that cronassial treated peripheral neural pathological changes in diabetes mellitus.The pos- sible mechasim is that cronassial promotes the grouth of peripheral nerve and recovers the func- tion of mervous cells rapidly and cronassial can enter the cell membrane to activate Na^+—K^+— ATP enzyme and possess the function of ease pain of the peripheral neures.

关 键 词：糖尿病 周围神经病变 山梨醇 肌醇 康络素 

分 类 号：R587.2[医药卫生—内分泌]