硫普罗宁的合成工艺研究  

Studies on Synthetic Process of Tiopronin

作　　者：杨静华[1] 陈胥卓[1] 章雁[1] 曹振威[1] 

机构地区：[1]湖北省医药工业研究院,武汉430061

出　　处：《中国药师》2005年第8期631-633,共3页China Pharmacist

摘　　要：目的:改进硫普罗宁的合成工艺。方法:以丙酸为起始原料,经溴化、取代、缩合、置换、水解反应合成硫普罗宁,对置换剂硫代苯甲酸的合成方法进行了改进。结果:对各步反应条件进行了优化,总收率达到66．1％,高于文献报道的38．2％。结论:合成工艺操作简便,提高了收率,降低了成本,适合工业化生产。Objective： To improve the synthetic process of tiopronin. Method： The target compound was synthesized from propionic acid via bromination, substitution, condensation, replacement and hydrolysis. The process of synthesizing the replacement agent thiobenzoic acid was improved. Result： The reaction conditions of every step of the proces were optimized. The total yield had been increased from 38.2 % （ reported by literature） to 66.1%. Conclusion： This improved synthetic process has advantages of convenient operation, higher yield, and lower cost. It is suitable for industrial production.

关 键 词：硫普罗宁 工艺改进 化学合成 

分 类 号：TQ460.31[化学工程—制药化工]