地尔硫对肾移植受者他克莫司用量及肾功能的影响  

Influences of Diltiazem on Dosage of Tacrolimus and Renal Function of Renal Graft Recipients

作　　者：黄赤兵[1] 张银甫[1] 范明齐[1] 王平贤[1] 贾维胜[1] 

机构地区：[1]第三军医大学新桥医院泌尿外科,重庆400037

出　　处：《中国药师》2005年第8期653-655,共3页China Pharmacist

摘　　要：目的:观察地尔硫革(Dil)减少肾移植受者他克莫司(Tac)用量、改善肾功能的效能。方法:肾移植术后3周,将Dil 用于36例服用Tac的肾移植受者,以同期30例受者为对照,观察两组用药后1年内Tac用量和肾功能变化。结果:用Dil后 1周,该组Tac血浓度平均升高56％,术后12月内,每例Tac用量平均较对照组少380 mg,两组Tac血浓度无显著差异(P> 0．05);12月时,Dil组血肌酐明显低于对照组(126．1±36．3 vs．145．8±41．5μmol·L-1,P<0．05)。结论:Dil可明显减少肾移植受者的Tac用量,对移植肾功能亦具有保护作用。Objective： To observe the influences of dihiazem （Dil） on reducing the dosage of tacrolimus （Tac） and improving renal function in renal graft recipients. Method： Dil was used in 36 renal graft recipients after receipting renal graft for 3 weeks. Another 30 renal graft recipients with no Dil intake served as control group 3 weeks after operations. The dosage of Tac and renal function were compared between the two groups in a one - year clinical trial. Result： A significant increase of Tac blood concentration level （ 56% by average） had been observed in Dil group after one week. After 12 months, less Tac intake was needed in Dil group （380mg per case） and the Tac blood concentration had no significant differences between two groups. The creatinine levels of Dil group were lower than that in control group significantly in the 12th month （ 126.1 ± 36.3 vs. 145.8 ± 41.5 μmol·L^-1 ,P 〈0.05 ）. Conclusion： Administration of Dil can reduce the dosage of Tac of renal graft recipients and may protect renal function as well.

关 键 词：地尔硫ZHUO 他克莫司 肾功能 肾移植 

分 类 号：R972.4[医药卫生—药品]