椎间盘突出症复发原因初步研究  

To explore the recurrent cause of intervertebral disc herniation initially

作　　者：彭笳宸[1] 张天宏[1] 

机构地区：[1]遵义医学院第一附属医院骨科,贵州遵义563003

出　　处：《中国矫形外科杂志》2005年第15期1130-1131,共2页Orthopedic Journal of China

基　　金：贵州省省长专项基金项目(No.2000-2)

摘　　要：[目的]检测突出椎间盘组织中免疫、炎症机理的代表产物表达情况,初步探索椎间盘突出症的复发原因及转归。[方法]以猪为实验动物,手术制作椎间盘突出的动物模型,采用免疫组化的方法对突出椎间盘组织中免疫复合物及巨噬细胞的浸润现象尤其是远期表现进行了观察。[结果]52例突出椎间盘组织中有22例出现免疫复合物的阳性表达,明显晚于巨噬细胞的出现;在晚期出现了局部巨噬细胞浸润减少后免疫复合物仍呈较高阳性表达的现象。[结论]突出的椎间盘组织中存在的免疫复合物是椎间盘突出症引起下腰痛及坐骨神经痛的重要病理生理基础之一,并很可能是椎间盘突出症复发或者保守治疗效果欠佳的关键因素。[Objective] To determine the presence of immune and inflammatory representative product in the herniated disc tissue, and explore initially the recurrent cause and change of intervertebral disc herniation. [Method] The pigs were used as animal models after surgery in the intervertebral disc. Macrophage infiltration and presence of immune complexes were observed with the immunohistochemical method in herniated disc tissue in different times, especially in later period. [Result] Immune complexes were found in 22 of 52 herniated disc tissue, and they not only appeared later than macrophage obviously, but remain more positive presence after the reduction of macrophage in the later period. [ Conclusion] The immune complexes in the herniated disc tissue may be one important factor in the pathogenesis of intervertebral disc herniation, and may be a factor of the recurrence of intervertebral disc herniation, even the bad curative effect after non-operative treatment.

关 键 词：椎间盘突出症 复发 病理生理学 免疫复合物 腰痛 坐骨神经痛 

分 类 号：R681.53[医药卫生—骨科学]