豚鼠组织中磷脂酰乙醇胺生物合成能力的比较  

Comparison study of phosphatidylethanolamine biosynthesis power in guinea pig tissues

作　　者：吕俊[1] 吕灿群[1] 

机构地区：[1]皖南医学院生物化学教研室,安徽芜湖241001

出　　处：《皖南医学院学报》2005年第3期167-169,共3页Journal of Wannan Medical College

基　　金：安徽省教育厅自然科学研究基金项目 (97JL15 8)

摘　　要：目的　探讨豚鼠不同组织中磷脂酰乙醇胺生物合成的能力及其生理意义。方法　使用[3 H] 乙醇胺作为原料物,经腹膜内注射至豚鼠体内,检查该标记物在含乙醇胺磷脂的重要组织内的摄取和结合能力。结果　显现标记乙醇胺进入磷脂酰乙醇胺具有组织特异性,大脑中磷脂酰乙醇胺的生物合成能力最强,占38.3% ,其次为肝脏和肾脏,合成能力最弱的是心脏,仅占12 .1%。结论　大脑是合成磷脂酰乙醇胺的主要器官,这与其重要的生理功能相吻合。Objective To approach the biosynthesis power of phosphatidylethanolamine in affecting guinea pig tissues and physiological change. Methods Experimental guinea pigs were injected interperitoneally with [^3H]-ethanolamine and the process of uptake and incorporation into the various ethanolamine-containing phospholipids of the major tissues was examined. Results The results revealed that the ethanolamine into phosphatidyl ethanolamine demonstrated specificity in tissues. The biosynthesis power in brain was prominent（38.3 % ）and followed by liver and kidney tissues. Less power was seen in heart tissues with a percentage of 12. 1%.Conclusion The brain is major organ in biosynthesis of phosphatidyl ethanolamine and it is identical with its important physiological function.

关 键 词：乙醇胺 磷脂酸乙醇胺 生物合成 豚鼠 

分 类 号：R344.52[医药卫生—基础医学]