灭梭威的合成  

Synthesis of Methiocarb

作　　者：郑鹛[1] 杜晓华[1] 徐振元[1] 

机构地区：[1]浙江工业大学催化加氢研究中心,绿色化学合成技术国家重点实验室培育基地,杭州310014

出　　处：《农药》2005年第8期361-362,共2页Agrochemicals

摘　　要：以3,5-二甲基苯酚为起始原料经乙酰化、甲硫化、水解和胺基甲酰化反应合成了灭梭威。该路线原料易得、操作简便、收率较高。三步反应合成中间体3,5-二甲基-4-甲硫基苯酚收率达到85.9%,合成灭梭威总收率达到62.0%。Using 3,5-dimethylphenol as a starting reagant, methiocarb was synthesized by acetylation, sulfenylation,hydrolysis, and carbamylation. The starting reagant for this synthesis pathway is easy to obtain, the process is convenient and simple, and product yield was relatively high. Yield for the step 3 intermediate, 3,5-dimethyl-4-methylthio-xylenol, was 85.9%, while methiocarb was produced with an overall yield of 62.0%.

关 键 词：灭梭威 3 5’-二甲基-4-甲硫基苯酚 合成 

分 类 号：TQ453[化学工程—农药化工]