鸡急性血源性骨髓炎的药物治疗研究  

EXPERIMENTAL DRUG THERAPY FOR ACUTE HEMATOGENEOUS OSTEOMYELITIS IN CHICKENS

作　　者：王明华[1] 江让[1] 

机构地区：[1]浙江医科大学附属第二医院骨科

出　　处：《浙江医科大学学报》1989年第2期49-52,共4页

摘　　要：用鸡急性血源性骨髓炎模型进行4周药物治疗对照研究.105只鸡,分7组,每组15只鸡.有①正常组对照,②实验对照,③青霉素+庆大霉素,④青霉素+庆大霉素+阿斯匹林,⑤邻氯青霉素,⑥短疗程邻氯青霉素(2周),⑦邻氯青霉素延迟48小时治疗.结果发现目前临床常用的青霉素+庆大霉素治疗由耐青霉素金葡菌引起的急性血源性骨髓炎效果并不理想,而邻氯青霉素疗效甚好.实验证明抗菌素必须尽早使用,延迟治疗则疗效下降.邻氯青霉素治疗4周或2周,结果一样满意,支持抗菌素疗程不必过长的新观点.新近观点还认为前列腺素对急性骨髓炎的发生发展起重要作用,但本文实验未能显示阿斯匹林有辅助治疗效用.A 4-week drug therapy investigation in the chicken model of acute hematogeneous osteomyelitis has been performed. 105 chickens Mere divided into the following 2 control and 5 drug treated groups, with 15 chickens each groups ①the normal control, ②the experimental control, ③the penicillin and gentamycin treated group, ④the penicillin, gentamycin plus aspirin treated group, ⑤the cloxacillin treated group, ⑥the 2-week cloxacillin treated group and ⑦the cloxacillin treated group with 48h delay. The result has shown penicillin and gentamycin, now used extensively, have poor effect on acute hematogeneous osteomyelitis caused by penicillin resistant staphylococcus aureus, whereas cloxacillin exerts far better effect. It has also been confirmed that antibiotics should be prescribed as soon as possible. Both the 2-week and 4-week cloxacillin treatments yield similar result, which supports the new idea that there is no need for a longer-than-2-3 week antibiotics treatment. It is recently suggested that prostaglandin has a special function on the development of osteomyelitis. However our experiment fails to show the effect of aspirin in osteomyelitis treatment.

关 键 词：骨髓炎 抗菌素 鸡 

分 类 号：R681.2[医药卫生—骨科学]