尿TGFβ_1含量的检测对原发性肾病综合征诊治的临床意义  

Clinical Investigation on Detection and Diagnostic Signifi cance of Urinary Transforming Growth Factor-β_1 in Patients with Prima ry Nephronic Syndrom

作　　者：曾瑜[1] 陈明[2] 王开正[1] 张帆[2] 邓正华[1] 

机构地区：[1]泸州医学院附属医院检验科,四川泸州646000 [2]泸州医学院附属医院肾内科,四川泸州646000

出　　处：《现代检验医学杂志》2005年第4期65-67,共3页Journal of Modern Laboratory Medicine

摘　　要：目的探讨检测尿中转化生长因子β1(TGFβ1)在原发性肾病综合征中的临床意义。方法用间接酶联免疫法测定25例原发性肾病综合征患者血、尿中(TGFβ1)的含量,并与15例正常对照组进行比较,同时与血浆白蛋白浓度和24h尿蛋白总量进行相关性比较。结果原发性肾病综合征患者的24h尿蛋白总量明显高于实验对照组(P<0.01),而血清清蛋白含量明显低于实验组(P<0.01)。尿中TGFβ1的含量也明显高于实验对照组。血TGFβ1的含量在实验组和对照组之间无显著差异。原发性肾病综合征患者尿TGFβ1含量与24h尿蛋白含量(TP)呈明显正相关关系,TGFβ1=189.54+5.89×TP,(r=0.62,P<0.01),而尿中TGFβ1含量与血清清蛋白之间无明显相关关系(r=0.04,P>0.05)。血TGFβ1和24h尿蛋白总量及血清清蛋白之间却无明显的相关关系(r=0.13,r=0.19,P>0.05)。结论检测尿中TGFβ1的含量有助于评价原发性肾病综合征的发生和进展。Objective To explore the clinical detection and diagnostic significance of urinary transforming growth factor-β1 （TGFβ1） in patients with primary nephronic syndrom. Methods The level of urinary and serum TGFβ1 were measured in 25 patients with primary nephronic syndrom and 15 healthy subjects by means of enzyme-linked immunosorbent assary.The relationship among urinary TGFβ1 and amount urinary protein,serum albumin and serum TGFβ1 were also observed in this study. Results The level of amount urinary protein in primary nephronic syndrom increased remarkably compared with control group （P〈0.01）. The level of serum albumin in primary nephronic syndrom decreased remarkably compared with control group（P〈0.01 ）. The level of urinary TGFβ1 in nephronic syndrom increased remarkably compared with control group （P〈0. 01）. There was not difference in serum TGFβ1 between primary nephronic syndrom and control group. A positive correlation between urinary TGFβ1 and amount urinary protein was found in primary nephronic syndrom. TGFβ1 =189.54＋ 5.89 × TP, （r= 0.62 ,P〈0.01）. There was not a positive correlation between urinary TGFβ1 and serum albumin（r=0.04,P〈0.05） and there was not a positive correlation amount urinary TGFβ1 and urinary protein/serum albumin （r=0. 13,r=0.19,P〉0.05） in primary nephronic syndrom. Conclusion Determination urinary TGFβ1 is available for evaluating the progressive renal injury in primary nephronic syndrom.

关 键 词：转化生长因子Β1 原发性肾病综合征 尿液 间接酶联免疫法 

分 类 号：R446.6[医药卫生—诊断学] R692.5[医药卫生—临床医学]