抗淋巴细胞球蛋白联合环胞霉素A治疗儿童重型再生障碍性贫血早期疗效观察  

Observation on the early effects of antilymphocyte globulin and cyclosporine A treatment in children with severe aplastic anemia

作　　者：卢俊[1] 柴忆欢[1] 曹幼甫[2] 何海龙[1] 李建琴[1] 邓海珍[2] 

机构地区：[1]苏州大学附属儿童医院血液科,215003 [2]苏州大学病理教研室

出　　处：《中国小儿血液》2005年第3期103-105,共3页China Child Blood

摘　　要：目的探讨提高儿童重型再生障碍性贫血(SAA)早期疗效的办法。方法采用随机对照方法,比较抗淋巴细胞球蛋白(ALG)和环胞霉素(CSA)联合治疗组与单用CSA组治疗儿童SAA的早期疗效(6个月)。结果联合治疗组和CSA组的总有效率分别为(84%)、(60%),P<0·05,联合治疗可降低早期死亡率,缩短脱离红细胞和血小板的输注时间。结论ALG联合CSA治疗儿童SAA是安全的且疗效佳,应作为一线方案。Objective To investigate a way of the improvement of the early therapeutic efficacy of children severe aplastic anemia（SAA）. Methods On the basis of randomized and controlled trial, 53 patients with SAA were randomly assigned to the treatment with antilympholyte globulin （ALG） and cyclosporine A （CSA） as the combined group or with only CSA as the CSA group, the short term therapeutic effectiveness of the two regimens was observed and compared at the six month after treatment. Results The combined regimen showed to be obviously superior to single - CSA therapy in SAA. Among 53 cases, the total response rate to the combined group was higher than that of the CSA group （84%、60%, P 〈 0.05）. In combined group, there were lower rates of early death, shorter time of transfusion dependence associated with hemoglolbin and platelet on six months after treatment. Conclusion The combination of ALG and CSA for treatment of children SAA should be a first - line therapy regimen, Which is safe and effective.

关 键 词：抗淋巴细胞球蛋白 环胞霉素A 儿童 重型再生障碍性贫血 早期 SAA 免疫抑制 

分 类 号：R725.5[医药卫生—儿科]