妊娠妇女血清总胆汁酸的变化及临床意义  

Level of Total Bile Acid in Serum of Women During Normal Pregnancy

作　　者：林广玲[1] 向晓光[1] 邱树彬[1] 刘波[1] 陈小凤[1] 

机构地区：[1]汕头大学医学院第二附属医院,广东汕头515041

出　　处：《实用医技杂志》2005年第08A期2027-2028,共2页Journal of Practical Medical Techniques

摘　　要：目的:了解正常孕妇血清总胆汁酸的含量,以及在妊娠过程中总胆汁酸的变化特征及临床意义。方法:采用BACKMANCX9全自动生化仪检测136例正常孕妇、35例产妇和52例非孕育龄妇女血清总胆汁酸(TBA)、总胆红素(TBIL)及直接胆红素(DBIL),丙氨酸氨基转移酶(ALT)。结果:正常妊娠过程血清TBA、TBIL、DBIL、ALT四项指标均有升高趋势,TBA浓度在中孕时开始明显升高,而其他三项指标则到晚孕时才显著升高,产后组TBA、ALT水平明显低于晚孕组,接近对照组水平。结论:对于妊娠过程TBA持续升高,且明显高于同孕龄正常孕妇,应定期作TBA检测和动态观察,有利于妊娠肝内胆汁瘀积症(ICP)及早诊治。Objective To explore the changes of total bile acid （TBA） in serum of women during normal pregnancy. Methods The levels of TBA ,total bilirubin （TBIL） ,direct bilirubin （DBIL） ,alanine transamlnase（ALT） were detected by BACKMAN CX9 analyzer. Results Compared with those of control group ,the level of TBA of pregnant women in the Ⅱ and Ⅲ gestational period was significant increased, the levels of TBIL,DBIL and ALT in the Ⅲ gestational period were significant increased. The levels of TBA and ALT in postpartum group were decreased than those of the women during normal pregnancy in Ⅲ gestational period. Conclusion The level of TBA of pregnant women increase with gestational period prolonged. It is a sengitiveindexfor diagnosis of intrahepatic cholestasis.

关 键 词：总胆汁酸 妊娠肝内胆汁瘀积症 总胆红素 妊娠妇女 血清 

分 类 号：R446.1[医药卫生—诊断学]