阿奇霉素片的茜素红荷移分光光度法测定  

Determination of Azithromycin Tablets by Spectrophotometry Based on Charge-transfer Reaction with Alizarin Red

作　　者：蒋晔[1] 刘红菊[1] 薛娜[1] 郝晓花[1] 

机构地区：[1]河北医科大学药学院,河北石家庄050017

出　　处：《中国医药工业杂志》2005年第8期498-500,共3页Chinese Journal of Pharmaceuticals

摘　　要：阿奇霉素与茜素红在乙醇-水溶液中发生荷移反应,由此建立了荷移分光光度法测定阿奇霉素片的含量。荷移反应生成1∶2型络合物,最大吸收波长为538nm,摩尔吸收系数为1.23×104L·mol-1·cm-1。阿奇霉素在10～60μg/ml浓度范围内线性关系良好。含量测定结果与HPLC法结果基本相符。A spectrophotometric method based on the charge-transfer reaction between azithromycin and alizarin red in aqueous ethanolic solution was established for the determination of azithromycin tablets. The composition ratio of the complex was 1 ：2, and the apparent molar absorptivity was 1.23 × 10^4 L·mol^-1.cm^-1 at maximum absorption wavelength of 538nm. The calibration curve was linear in the range of 10 - 60μg/ml. The results were comparable with those by HPLC.

关 键 词：阿奇霉素 茜素红 荷移反应 分光光度法 测定 

分 类 号：TQ460.72[医药卫生—药物分析学] O657.72[化学工程—制药化工]