Structural Characterization and Relaxivity Study of a New Paramagnetic Mn（Ⅱ） Complex of DTPA-BpABA  

作　　者：刘迎春 张静 罗权 马淑兰 许妙琼 朱文祥 

机构地区：[1]Department of Chemistry, Beijing Normal University, Beijing 100875, China [2]Analytical and Testing Center, Beijing Normal University, Beijing 100875, China

出　　处：《Chinese Journal of Chemistry》2005年第8期1012-1016,共5页中国化学（英文版）

基　　金：Project supported by the Municipal Natural Science Foundation of Beijing （No. 2022011）.

摘　　要：X-ray single crystal analysis of a new paramagnetic manganese（Ⅱ） complex with DTPA-BpABA （a DTPAbisamide derivative）, Mn（DTPA-BpABA）·4H2O, shows that four oxygen atoms and three nitrogen atoms from the ligand coordinate to Mn（Ⅱ） cation, forming a seven-coordinate distorted pentagonal bipyramid polyhedron. In the crystal, the carboxyl groups and the nitrogen atoms extensively form hydrogen bonds with the lattice water molecules, building a 3D-network. The relaxometric study indicates that the R1 value of the paramagnetic manganese（Ⅱ）complex is 5.12 mmol·L·s^-1. The higher R1 value means that this complex may find an application in magnetic resonance imaging （MRI） technique.X-ray single crystal analysis of a new paramagnetic manganese（Ⅱ） complex with DTPA-BpABA （a DTPAbisamide derivative）, Mn（DTPA-BpABA）·4H2O, shows that four oxygen atoms and three nitrogen atoms from the ligand coordinate to Mn（Ⅱ） cation, forming a seven-coordinate distorted pentagonal bipyramid polyhedron. In the crystal, the carboxyl groups and the nitrogen atoms extensively form hydrogen bonds with the lattice water molecules, building a 3D-network. The relaxometric study indicates that the R1 value of the paramagnetic manganese（Ⅱ）complex is 5.12 mmol·L·s^-1. The higher R1 value means that this complex may find an application in magnetic resonance imaging （MRI） technique.

关 键 词：manganese（Ⅱ） complex crystal structure relaxivity study contrast agent 

分 类 号：O614.711[理学—无机化学] R981[理学—化学]