阿托伐他汀改善陈旧性心肌梗死患者心功能及其运动耐量的作用  

An effect of atorvastatin on cardiac function and exercise tolerance in patients with remote myocardial infarction

作　　者：林晓云[1] 肖立中[2] 江志平[2] 

机构地区：[1]广东韶关大学医院,512026 [2]广东省粤北人民医院

出　　处：《实用心脑肺血管病杂志》2005年第4期193-195,共3页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的观察阿托伐他汀对血脂正常的陈旧性心肌梗死病人心功能及运动耐量的治疗影响。方法选择57例陈旧性心肌梗死病人,随机分为2组,分别给予消心痛10mg口服,每日三次,连用8周或阿托伐他汀10mg口服,每日一次连用8周,并比较两组每周心绞痛发作次数、硝酸甘油消耗量,心功能及运动耐量。结果阿托伐他汀减少心绞痛发作次数与硝酸甘油消耗量,而运动导致出现ST段压低1mm与心绞痛所需时间增加,ST段缺血型下移明显减少;左室射血分数、心输出量左室短轴缩短分数均增加,但左室舒张末期内径无明显变化。结论阿托伐他汀可改善运动诱发的心肌缺血,并提高心功能及运动耐量。Objective To evaluate the effect of atorvastatin on cardiac function and exercise tolerance in patients with remote myocardial infarction. Methods 57 patients with remote myocardial infarction were given isosorbide dinitrate or atorvastatin by mouth for 8 weeks randomly, Exercise tolerance was evaluated by treadmill exercise testing,cardiac function by Doppler ultrasound respectively before and after therapy. Results After treatment in atorvastatin group,angina petoris attack frequency and consumption of nitroglycerin weekly were decreased obviously;the time for inducing angina and 0. 1 mv ST segment depression and ∑ ST depression by exercise were improved markedly（ P 〈 0. 01 ）. Left verltricular ejecting fraction,fractional shortening,cardiac outputand increased（ P 〈 0.01 ） , Left ventrieular end-diastole diameter did not decrease（ P 〉0. 05）. Conclusion Atorvastatin has obvious anti-ischemie efficacy in patients with remote myocardial infarction,and can improve myocardial ischemia, cardiac function and exercise tolerance.

关 键 词：阿托伐他汀 陈旧性心肌梗死 心功能 运动耐量 

分 类 号：R542.22[医药卫生—心血管疾病]