表观遗传学DNA甲基化与非创伤性产前诊断  

DNA methylation in epigenetics and noninvasive prenatal diagnosis

作　　者：贾颐舫 李学哲 吴爱华 

机构地区：[1]山东省计划生育科研所优生技术重点实验室,山东济南250002

出　　处：《国外医学（妇幼保健分册）》2005年第4期253-255,共3页Foreign Medical Sciences (Section of Maternal and Child Health)

摘　　要：表观遗传学研究与DNA序列改变无关,仅发生表现型改变的过程,DNA甲基化是表观遗传学最具特征的标志之一,DNA甲基化技术的进展将其应用领域扩大到非创伤性产前诊断。甲基化特异性PCR可快速、灵敏地根据胎儿和母亲之间DNA甲基化的差异从母血浆中检测胎儿DNA。Epigenetics only involves process of changes in phenotype instead of changes in DNA sequence of genes. One of the bestcharacterized epigenetic process is DNA methylation, which can be used in noninvasive prenatal diagnosis. Methylation-specific PCR（MSP） can detect rapidly and sensitively fetal DNA in maternal plasm according to difference in DNA methylation between fetus and mother.

关 键 词：表观遗传学 DNA甲基化 甲基化特异性PCR 非创伤性产前诊断 

分 类 号：R714.5[医药卫生—妇产科学]