酮洛芬聚氰基丙烯酸正丁酯毫微粒制备工艺研究  

Preparation of ketoprofen-polybutylcyanoacrylate-nanoparticles

作　　者：肖正华[1] 吕凤林[2] 张梦军[1] 任建敏[1] 王振维[1] 

机构地区：[1]第三军医大学医学检验系,重庆400038 [2]第三军医大学大坪医院野战外科研究所,重庆400042

出　　处：《西南国防医药》2005年第2期150-153,共4页Medical Journal of National Defending Forces in Southwest China

基　　金：重庆市2002年攻关课题(7432)。

摘　　要：目的:制备酮洛芬聚氰基丙烯酸正丁酯毫微粒(KP PBCA NP)。方法:采用乳化聚合法制备空白PBCA NP,以粒径为指标,应用L9(34)正交试验优化处方工艺;吸附法制备KP PBCA NP,以包封率、载药量为指标,应用U10(108)均匀法设计实验,进行条件优化。结果:制备PBCA NP的优化条件为反应液pH2～3,PluronicF68的含量为1.0%～1.5%,优化条件下制备PBCA NP平均粒径为50nm;在制备KP PBCA NP时,当反应液的pH值为1,PBCA含量为0.5%,KP含量为0.8mg/ml时,可获得较高的包封率(平均为95.64%)和载药量(15.32%)。结论:控制工艺条件,可制备不同粒径的PBCA NP作为各种药物载体,并且可以从此为载体制备可用于注射给药的KP PBCA NP。Objective： To prepare ketoprofen - polybutylcyanoacrylate - nanoparticles（KP - PBCA - NP）. Methods： The PBCA - NP was firstly prepared with the emulsion polymerization method and L9（34） of orthogonal - design experiments was used for seeking the optimum formulation and technique. Then the KP - PBCA - NP was prepared by absorption and the factors that influenced the entrapment efficiency and quantity of drug - load were optimized with the U10（108） of Uniform design. Results.. The pH 2 to 3, 1.0% PBCA and 1.0% to 1.5% dextrin 70 was the optimum conditions for the preparation of PBCA - NP, and the diameter of PBCA - NP was about 50 nm in this condition. The optimum condition for preparation of KP- PBCA- NP was pH 1, 0. 5% PBCA and 0. 8% mg/ml KP,and the entrapment efficiency and quantity of drug - load of KP - PBCA - NP were 95.64% and 15. 32%, respectively. Conclusion..Under control conditions, PBCA - NP with different diameters can be prepared and used to load many kinds of drugs;meanwhile,injectable KP - PBCA - NP can be prepared.

关 键 词：酮洛芬 聚氰基丙烯酸正丁酯 毫微粒 均匀设计 

分 类 号：R94[医药卫生—药剂学]