冠心病患者临床表现、血压及血脂水平与血清C反应蛋白的关系  

Associations of the clinical manifestations,levels of blood pressure and blood lipid with the serum level of C-reactive protein in patients with coronary heart disease

作　　者：李月华[1] 徐琛华[1] 董利军[1] 刘晓红[1] 姜坚[1] 

机构地区：[1]上海第二医科大学附属新华医院心内科,上海市200092

出　　处：《中国临床康复》2005年第27期36-37,共2页Chinese Journal of Clinical Rehabilitation

摘　　要：目的:观察不同临床表现、血压水平、血脂水平冠心病患者C反应蛋白水平差异。方法:①选择2001-08/2003-05上海第二医科大学附属新华医院心内科住院的冠心病患者110例为冠心病组,男66例,女44例。②根据冠心病患者临床表现,将其分为2个亚组:心绞痛组45例,急性心肌梗死组65例。根据冠心病患者血清胆固醇、三酰甘油水平将其分成4个亚组:血脂正常组45例,单纯高胆固醇血症组28例,单纯高三酰甘油血症12例,总胆固醇和三酰甘油均高组25例。根据冠心病患者血压水平将其分成2个亚组:高血压组65例和血压正常组45例。③同期选择上海第二医科大学附属新华医院心内科住院的非冠心病患者31例为对照组,男15例,女16例。纳入对象均知情同意。④血清C反应蛋白水平测定采用散射浊度法;血脂测定采用酶法。⑤计量资料采用方差分析及t检验;各因素间的相关性研究用线性相关分析。结果:冠心病患者110例,非冠心病患者31例均进入结果分析。血清C反应蛋白水平:冠心病组患者明显高于对照组犤(12.54±12.15),(5.32±4.64)mg/L,P<0.01犦;心绞痛组、心肌梗死组明显高于对照组犤(10.76±12.28),(16.04±16.53),(5.32±4.64)mg/L,P<0.01犦,而心绞痛组与心肌梗死组相近;单纯高总胆固醇血组、单纯高三酰甘油血症、总胆固醇和三酰甘油均高组明显高于血脂正常组犤(13.85±13.07),(14.09±13.03),(13.53±16.83),(12.71±11.68)mg/L,P<0.05犦。而高脂血症各组相近;高血压组略高于血压正常组,但差异不明显犤(16.77±15.60),(16.04±13.45)mg/L,P<0.05犦。结论:冠心病患者血清C反应蛋白水平较非冠心病患者高。在有高血压、高血脂等合并症冠心病患者中,C反应蛋白浓度也较无这些合并症的患者高。提示C反应蛋白对动脉粥样硬化的发生发展有一定的预测作用。AIM： To observe the difference of level of C-reactive protein in patients with coronary heart disease with different clinical manifestations, levels of blood pressure and blood lipid. METHODS： ① Totally 110 inpatients with coronary heart disease （coronary heart disease group, 66 males and 44 females） were selected from the Department of Cardiology, Xinhua Hospital affiliated to the Shanghai Second Medical University between August 2001 and May 2003. ②According to the clinical manifestations, the patients were divided into 2 subgroups： angina group （n=45） and acute myocardial infarction group （n=65）, According to the serum levels of＇cholesterol and triglyeeride, they patients were divided into 4 subgroups： normal blood lipid group （n=45）, simple hypereholesterolemia group （n=28）, simple hypertriglyceridemia group （n=12） and hypereholestemlemia＋ hypertriglyeeridemia group （n=25）; According to the level of blood pressure, the patients were divided into 2 subgroup_s： hypertension group （n=65） and normal blood pressure group （n=45） .③ Another 31 inpatients without coronary heart disease （control group, 15 males and 16 females） in the Department of Cardiology, Xinhua Hospital affiliated to the Shanghai Second Medical University between August 2001 and May 2003 were involved in the study voluntarily. ④The serum level of C reactive protein was determined with the method of scattering turbidity, and blood lipid was detected with the enzyme method. ⑤ The measurement data were compared with the analysis of variance and t test, and the correlation among the factors were studied with the linear correlation analysis. RESULTS： All the 110 patients with coronary heart disease and 31 patients without coronary heart disease were involved in the analysis of resuits. Serum level of C reactive protein： It was obviously higher in the coronary heart disease group than in the control group [（12.54±12.15）,（5.32±4.64） mg/L, P 〈 0.01], obviously higher in the a

关 键 词：冠状动脉疾病 动脉硬化 心肌梗塞 心绞痛 C反应蛋白质 

分 类 号：R541.4[医药卫生—心血管疾病]