肾移植术后患者骨代谢的改变  

Variation of biochemical bone markers in renal transplant recipients

作　　者：米华[1] 邓耀良[1] 吴闯[2] 李盛宽[1] 刘德云[1] 

机构地区：[1]广西医科大学第一附属医院器官移植中心,南宁530021 [2]广西医科大学第一附属医院药剂科

出　　处：《临床泌尿外科杂志》2005年第8期455-457,共3页Journal of Clinical Urology

摘　　要：目的:研究肾移植术后患者骨代谢生化指标的改变。方法:采用竞争性放射免疫分析法测定30例肾移植患者和25例健康献血者的血清骨代谢生化指标:骨钙素(BGP)、降钙素(CT)、甲状旁腺激素(PTH)和25羟基维生素D(25OHD)、Ⅰ型胶原羧基端交联肽原(ICTP)和Ⅰ型前胶原氨基端伸展肽(PINP)水平。结果:肾移植术后患者的BGP、PINP和ICTP水平明显高于正常对照组(P<0.01),但两组的CT、25OHD和PTH水平差异无统计学意义(P>0.05)。结论:肾移植术后患者出现明显的骨代谢紊乱,主要表现为血清成骨细胞活性增强,同时伴有破骨细胞功能增强,骨转换活跃,其发病机制可能主要与术后长期使用免疫抑制剂有关。Objective：To evaluate the variations of serum biochemical bone markers in renal transplant recipients. Methods： Serum level of Osteocalcin （ BGP）, Calcitonin（CT）, Parathyroid hormone（ PTH ）, 25 hydroxyvitamin D（25-OH-D）, Cross linked carboxyterminal telopeptide of type Ⅰ collagen （ICTP）, Aminoterminal propeptide of type Ⅰ procollagen （PINP） were measured by radioimmunoassay in 30 renal transplant recipients and 25 healthy people. Results：The serum level of BGP, PINP and ICTP were significantly increased in the renal transplant recipients （ P〈0.01）,but CT, 25-OH-D and PTH level were not significantly different in renal transplant recipients compared with control group（ P〉0.05）. Conclusions： Markers of hone turnover were increased in renal transplant recipients, which might be related to the immunosuppression therapy.

关 键 词：骨生化指标 肾移植 

分 类 号：R699.2[医药卫生—泌尿科学]