中老年男性血清氧化/抗氧化状态的监测及相关性研究  

Significance of monitoring the state of oxidant/antioxidant and blood lipid ,FBG in the middle and old age

作　　者：沈华[1] 许翔[1] 梁英妹[1] 

机构地区：[1]上海市第一人民医院,上海200080

出　　处：《现代医药卫生》2005年第16期2099-2100,共2页Journal of Modern Medicine & Health

摘　　要：目的:探讨监测中、老年体内氧化/抗氧化状态以及血脂、空腹血糖水平的临床意义。方法:测定青年对照组及中、老年人血清丙二醛(MDA),超氧化物歧化酶(SOD),谷胱甘肽过氧化物酶(GSH-PX),总抗氧化能力(T-AOC)及血总胆固醇(CHO)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、甘油三酯(TG)和空腹血糖(FBG)。结果:中、老年人组MDA、CHO、LDL、TG、FBG明显高于青年组,且老年组又明显高于中年组。中、老年人组中SOD、GSH-PX、T-AOC明显低与青年组,且老年组中SOD、T-AOC较中年组下降也有显著差异。结论:在中、老年人群中除血脂、血糖水平外,MDA、SOD、T-AOC、GSH-PX等几项指标也是评价中、老年人体内氧化应急、氧化/抗氧化能力客观指标,监测其水平,对老年病的防治具有很大的价值。Objective： In order to examine the related factors which lead to the aged disease, the state of oxidant/antioxidant, the content of blood lipid, blood sugar were investigated. Methods： 3 groups taken part in this survey were tested for the serum MDA,SOD,GSH - PX,T - AOC,blood lipid and fasting blood glucose, the tests between young controls and middle and aged groups were compared. Results： The serum MDA, SOD,LDL,TG, FBG in middle and aged groups were significantly higher than those in normal controls, which in the aged group were higher than those in the middle age group. The serum SOD, GSH - PX, T - AOC in middle and aged groups were lower than those in young controls. And the SOD,T- AOC in aged group were lower than those in middle age group.Conclusion：Apart from measuring the blood lipid and fasting blood glucose, it is also important to measure serum MDA, SOD, GSH - PX, T - AOC levels for monitoring the state of oxidant/antioxidant and preventing senile disease.

关 键 词：丙二醛 超氧化物歧化酶 谷胱甘肽过氧化物酶 总抗氧化能力 血脂 空腹血糖 

分 类 号：R446[医药卫生—诊断学]